Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 3267312..3267914 Replicon chromosome
Accession NZ_CP116970
Organism Escherichia coli strain CUVM3

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag PQP09_RS16225 Protein ID WP_000897305.1
Coordinates 3267312..3267623 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PQP09_RS16230 Protein ID WP_000356397.1
Coordinates 3267624..3267914 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP09_RS16195 (3262342) 3262342..3263127 + 786 WP_000059678.1 DeoR/GlpR family DNA-binding transcription regulator -
PQP09_RS16200 (3263226) 3263226..3263825 + 600 WP_001315111.1 glucose-1-phosphatase -
PQP09_RS16205 (3263819) 3263819..3264691 + 873 WP_000920762.1 virulence factor BrkB family protein -
PQP09_RS16210 (3264688) 3264688..3265125 + 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
PQP09_RS16215 (3265170) 3265170..3266111 + 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
PQP09_RS16220 (3266175) 3266175..3267083 - 909 WP_001162704.1 alpha/beta hydrolase -
PQP09_RS16225 (3267312) 3267312..3267623 + 312 WP_000897305.1 hypothetical protein Toxin
PQP09_RS16230 (3267624) 3267624..3267914 + 291 WP_000356397.1 NadS family protein Antitoxin
PQP09_RS16235 (3268519) 3268519..3268737 + 219 WP_001295676.1 CopG family transcriptional regulator -
PQP09_RS16240 (3268956) 3268956..3269198 + 243 WP_001086388.1 protein YiiF -
PQP09_RS16245 (3269528) 3269528..3270457 - 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
PQP09_RS16250 (3270454) 3270454..3271089 - 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
PQP09_RS16255 (3271086) 3271086..3271988 - 903 WP_000331377.1 formate dehydrogenase O subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T269566 WP_000897305.1 NZ_CP116970:3267312-3267623 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT269566 WP_000356397.1 NZ_CP116970:3267624-3267914 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References