Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2502449..2502681 Replicon chromosome
Accession NZ_CP116962
Organism Enterococcus faecalis strain DM86

Toxin (Protein)


Gene name txpA Uniprot ID C7CXQ5
Locus tag PO880_RS12090 Protein ID WP_002355568.1
Coordinates 2502565..2502681 (-) Length 39 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2502449..2502654 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PO880_RS12070 2497936..2499024 - 1089 WP_002396964.1 diacylglycerol kinase -
PO880_RS12075 2499043..2500473 - 1431 WP_272731453.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB -
PO880_RS12080 2500473..2501942 - 1470 WP_002368026.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA -
PO880_RS12085 2501942..2502247 - 306 WP_002355569.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC -
- 2502449..2502654 + 206 - - Antitoxin
PO880_RS12090 2502565..2502681 - 117 WP_002355568.1 putative holin-like toxin Toxin
PO880_RS12095 2502829..2504859 - 2031 WP_010710796.1 NAD-dependent DNA ligase LigA -
PO880_RS12100 2504985..2507243 - 2259 WP_202492283.1 DNA helicase PcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(3-35)


Sequences

Toxin        


Download         Length: 39 a.a.        Molecular weight: 4065.93 Da        Isoelectric Point: 5.9482

>T269544 WP_002355568.1 NZ_CP116962:c2502681-2502565 [Enterococcus faecalis]
MFLSVEAALGLMIGFATLVVTIIFGILALVLDNKNNRS

Download         Length: 117 bp

Antitoxin


Download         Length: 206 bp

>AT269544 NZ_CP116962:2502449-2502654 [Enterococcus faecalis]
AAAAGAGAGATATGCAGGAACATACCTCTCTAGTAGCCACTACTAGTTATAAGAACTAGCGGCTTACTGAGTTATTGGTT
TTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTTGTTGTCTAAGACAAGCGCTAAGATAC
CGAAGATAATGGTCACAACAAGTGTTGCAAAACCAATCATCAGTCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B4XLM6

Antitoxin

Download structure file

References