Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 355718..356224 Replicon chromosome
Accession NZ_CP116962
Organism Enterococcus faecalis strain DM86

Toxin (Protein)


Gene name txpA Uniprot ID S4BYM2
Locus tag PO880_RS01645 Protein ID WP_002392696.1
Coordinates 356081..356224 (+) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 355718..355916 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PO880_RS01620 350983..353115 + 2133 WP_010710871.1 DNA mismatch repair endonuclease MutL -
PO880_RS01625 353140..353694 + 555 WP_002354869.1 Maf family protein -
PO880_RS01630 353827..354264 + 438 WP_002354871.1 peptide-methionine (R)-S-oxide reductase MsrB -
PO880_RS01635 354439..355410 + 972 WP_002381060.1 ribose-phosphate diphosphokinase -
PO880_RS01640 355642..355785 + 144 WP_002392696.1 type I toxin-antitoxin system toxin PepG1 -
- 355718..355916 - 199 - - Antitoxin
PO880_RS01645 356081..356224 + 144 WP_002392696.1 type I toxin-antitoxin system toxin PepG1 Toxin
PO880_RS01650 356594..357244 - 651 WP_002367457.1 beta-phosphoglucomutase -
PO880_RS01655 357259..360003 - 2745 WP_025191898.1 glycosyl hydrolase family 65 protein -
PO880_RS01660 360265..360978 + 714 WP_002367455.1 trehalose operon repressor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5297.43 Da        Isoelectric Point: 10.6867

>T269535 WP_002392696.1 NZ_CP116962:356081-356224 [Enterococcus faecalis]
MSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Download         Length: 144 bp

Antitoxin


Download         Length: 199 bp

>AT269535 NZ_CP116962:c355916-355718 [Enterococcus faecalis]
TTTTTAGGGAATTGTGCTATAATGAAAATGAAAAGAGAGATATGCTTCAACATACCTCTCTGATGTAGAGCCGTTTAAGA
CGGTGACCGATTGTATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTATTGTCATTTTTAAGCAATT
TCACAATCAGTGCAATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S4BYM2

Antitoxin

Download structure file

References