Detailed information of TA system TA269527

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 271110..271447
• Replicon: chromosome
• Accession: NZ_CP116962
• Organism: Enterococcus faecalis strain DM86

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A1J6YG70
• Locus tag: PO880_RS01260
• Protein ID: WP_002396786.1
• Coordinates: 271304..271447 (-)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	271110..271372 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PO880_RS01255	266418..271109	+	4692	WP_010710853.1	WxL domain-containing protein	-
-	271110..271372	+	263	-	-	Antitoxin
PO880_RS01260	271304..271447	-	144	WP_002396786.1	putative holin-like toxin	Toxin
PO880_RS01265	271717..273333	-	1617	WP_010710855.1	phosphatase PAP2/LCP family protein	-
PO880_RS01270	274018..274656	+	639	WP_002378863.1	lytic polysaccharide monooxygenase	-
PO880_RS01275	274823..275815	-	993	WP_002394775.1	biotin--[acetyl-CoA-carboxylase] ligase	-
PO880_RS01280	275954..276169	+	216	WP_002354768.1	zinc ribbon domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5203.19 Da
• Isoelectric Point: 8.6626

>T269527 WP_002396786.1 NZ_CP116962:c271447-271304 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKEDNKK

Nucleotide

• Length: 144 bp

Antitoxin

Nucleotide

• Length: 263 bp

>AT269527 NZ_CP116962:271110-271372 [Enterococcus faecalis]
AAATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGATGGTCGTTGTGCTATA
ATAGTAATGAAAAGAGAGGTATGCGCCAACATACCTCTCTAGTGTAGAGCCGTTTCAGACGGTAGCGATTTTTAGTGATT
TATAAAAAATAACCGTGCTCGCTAAAGTTGACGGTTATTTTTTATTGTCTTCTTTAACAGCCTCTAGGATTCCGAAGATT
AACGTTGCGATAAAAGAACCGAA

Structures

Toxin

• AlphaFold DB: A0A1J6YG70

Antitoxin