Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4762439..4763041 Replicon chromosome
Accession NZ_CP116931
Organism Escherichia coli strain MLI106K1

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag NL422_RS23450 Protein ID WP_000897305.1
Coordinates 4762730..4763041 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NL422_RS23445 Protein ID WP_000356395.1
Coordinates 4762439..4762729 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL422_RS23410 (4758063) 4758063..4758965 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
NL422_RS23415 (4758962) 4758962..4759597 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
NL422_RS23420 (4759594) 4759594..4760523 + 930 WP_000027720.1 formate dehydrogenase accessory protein FdhE -
NL422_RS23425 (4760705) 4760705..4760947 - 243 WP_001309881.1 CopG family transcriptional regulator -
NL422_RS23430 (4761166) 4761166..4761384 - 219 WP_001295676.1 CopG family transcriptional regulator -
NL422_RS23435 (4761803) 4761803..4762081 - 279 WP_001315112.1 hypothetical protein -
NL422_RS23440 (4762133) 4762133..4762354 - 222 WP_001550354.1 hypothetical protein -
NL422_RS23445 (4762439) 4762439..4762729 - 291 WP_000356395.1 NadS family protein Antitoxin
NL422_RS23450 (4762730) 4762730..4763041 - 312 WP_000897305.1 hypothetical protein Toxin
NL422_RS23455 (4763270) 4763270..4764178 + 909 WP_001550353.1 alpha/beta hydrolase -
NL422_RS23460 (4764346) 4764346..4765260 - 915 WP_109553727.1 transposase -
NL422_RS23465 (4765273) 4765273..4766160 - 888 Protein_4453 hypothetical protein -
NL422_RS23470 (4766576) 4766576..4767517 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
NL422_RS23475 (4767562) 4767562..4767999 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T269513 WP_000897305.1 NZ_CP116931:c4763041-4762730 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10869.46 Da        Isoelectric Point: 10.8907

>AT269513 WP_000356395.1 NZ_CP116931:c4762729-4762439 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRHPSRTFEVDAMKIKEIRRASGLSQSKFAELISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References