Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 632641..633440 Replicon chromosome
Accession NZ_CP116931
Organism Escherichia coli strain MLI106K1

Toxin (Protein)


Gene name yhaV Uniprot ID F0JQM9
Locus tag NL422_RS03700 Protein ID WP_000347270.1
Coordinates 632641..633105 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID A0A0V9H1L4
Locus tag NL422_RS03705 Protein ID WP_001551693.1
Coordinates 633105..633440 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL422_RS03670 (627642) 627642..628076 - 435 WP_000948837.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
NL422_RS03675 (628094) 628094..628972 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
NL422_RS03680 (628962) 628962..629741 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
NL422_RS03685 (629752) 629752..630225 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
NL422_RS03690 (630248) 630248..631528 - 1281 WP_001551694.1 tagatose-bisphosphate aldolase subunit KbaZ -
NL422_RS03695 (631777) 631777..632586 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
NL422_RS03700 (632641) 632641..633105 - 465 WP_000347270.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
NL422_RS03705 (633105) 633105..633440 - 336 WP_001551693.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
NL422_RS03710 (633589) 633589..635160 - 1572 WP_001273738.1 galactarate dehydratase -
NL422_RS03715 (635535) 635535..636869 + 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
NL422_RS03720 (636885) 636885..637655 + 771 WP_072617374.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17806.22 Da        Isoelectric Point: 9.6924

>T269493 WP_000347270.1 NZ_CP116931:c633105-632641 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEEAH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12347.87 Da        Isoelectric Point: 4.6890

>AT269493 WP_001551693.1 NZ_CP116931:c633440-633105 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDTQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0V9NQ90

Antitoxin

Source ID Structure
AlphaFold DB A0A0V9H1L4

References