Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yafN-yafO (relBE)/YafO-YafN
Location 3827626..3828320 Replicon chromosome
Accession NZ_CP116925
Organism Escherichia coli strain MLI104K2

Toxin (Protein)


Gene name yafO Uniprot ID -
Locus tag NL420_RS19665 Protein ID WP_115223466.1
Coordinates 3827626..3828024 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name yafN Uniprot ID S1FJN6
Locus tag NL420_RS19670 Protein ID WP_000554757.1
Coordinates 3828027..3828320 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
- (3823286) 3823286..3823366 - 81 NuclAT_10 - -
- (3823286) 3823286..3823366 - 81 NuclAT_10 - -
- (3823286) 3823286..3823366 - 81 NuclAT_10 - -
- (3823286) 3823286..3823366 - 81 NuclAT_10 - -
NL420_RS19635 (3822626) 3822626..3823870 - 1245 WP_000189541.1 esterase FrsA -
NL420_RS19640 (3823962) 3823962..3824420 - 459 WP_001291990.1 xanthine phosphoribosyltransferase -
NL420_RS19645 (3824681) 3824681..3826138 + 1458 WP_001293003.1 cytosol nonspecific dipeptidase -
NL420_RS19650 (3826195) 3826195..3826716 - 522 Protein_3746 peptide chain release factor H -
NL420_RS19655 (3826715) 3826715..3826918 - 204 Protein_3747 RtcB family protein -
NL420_RS19660 (3827164) 3827164..3827616 - 453 WP_001059847.1 GNAT family N-acetyltransferase -
NL420_RS19665 (3827626) 3827626..3828024 - 399 WP_115223466.1 type II toxin-antitoxin system mRNA interferase toxin YafO Toxin
NL420_RS19670 (3828027) 3828027..3828320 - 294 WP_000554757.1 type I toxin-antitoxin system antitoxin YafN Antitoxin
NL420_RS19675 (3828372) 3828372..3829427 - 1056 WP_001226164.1 DNA polymerase IV -
NL420_RS19680 (3829498) 3829498..3830283 - 786 WP_000207587.1 putative lateral flagellar export/assembly protein LafU -
NL420_RS19685 (3830255) 3830255..3831967 + 1713 Protein_3753 flagellar biosynthesis protein FlhA -
NL420_RS19690 (3832191) 3832191..3832688 - 498 WP_072667535.1 REP-associated tyrosine transposase RayT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin YafO

(27-129)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15454.80 Da        Isoelectric Point: 8.0949

>T269468 WP_115223466.1 NZ_CP116925:c3828024-3827626 [Escherichia coli]
MRVFKTKLIRLQLTAEELDALTADFISYKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANVNNPFPPQLRQFSRT
NDEAHLVYCQGAFDEQAWLLIAILKPEPHKQARDNNQMHKIGKMAEAFRIRF

Download         Length: 399 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11233.81 Da        Isoelectric Point: 5.9050

>AT269468 WP_000554757.1 NZ_CP116925:c3828320-3828027 [Escherichia coli]
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKPIKARFRPSAARLEEITRRA
EKYLNDMTDDDFNDFKE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB S1FJN6

References