Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 702923..703616 Replicon chromosome
Accession NZ_CP116925
Organism Escherichia coli strain MLI104K2

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag NL420_RS03990 Protein ID WP_000415584.1
Coordinates 702923..703219 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag NL420_RS03995 Protein ID WP_000650107.1
Coordinates 703221..703616 (+) Length 132 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL420_RS03955 (698011) 698011..698325 - 315 WP_000958598.1 putative quinol monooxygenase -
NL420_RS03960 (698356) 698356..698937 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
NL420_RS03965 (699256) 699256..699588 + 333 WP_000917684.1 DUF2645 family protein -
NL420_RS03970 (699634) 699634..700983 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
NL420_RS03975 (700980) 700980..701639 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
NL420_RS03980 (701791) 701791..702183 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
NL420_RS03985 (702236) 702236..702718 + 483 WP_000183505.1 GyrI-like domain-containing protein -
NL420_RS03990 (702923) 702923..703219 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
NL420_RS03995 (703221) 703221..703616 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
NL420_RS04000 (703749) 703749..705356 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
NL420_RS04005 (705494) 705494..707752 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-97)

Antitoxin

(3-47)


Sequences


Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T269454 WP_000415584.1 NZ_CP116925:702923-703219 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp


Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT269454 WP_000650107.1 NZ_CP116925:703221-703616 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 3HI2


Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References