Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 595903..596702 Replicon chromosome
Accession NZ_CP116925
Organism Escherichia coli strain MLI104K2

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag NL420_RS03460 Protein ID WP_000347273.1
Coordinates 595903..596367 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag NL420_RS03465 Protein ID WP_001307405.1
Coordinates 596367..596702 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL420_RS03430 (590904) 590904..591338 - 435 WP_072667546.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
NL420_RS03435 (591356) 591356..592234 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
NL420_RS03440 (592224) 592224..593003 - 780 WP_000406209.1 PTS N-acetylgalactosamine transporter subunit IIC -
NL420_RS03445 (593014) 593014..593487 - 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
NL420_RS03450 (593510) 593510..594790 - 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
NL420_RS03455 (595039) 595039..595848 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
NL420_RS03460 (595903) 595903..596367 - 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
NL420_RS03465 (596367) 596367..596702 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
NL420_RS03470 (596851) 596851..598422 - 1572 WP_001273753.1 galactarate dehydratase -
NL420_RS03475 (598797) 598797..600131 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
NL420_RS03480 (600147) 600147..600917 + 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T269452 WP_000347273.1 NZ_CP116925:c596367-595903 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT269452 WP_001307405.1 NZ_CP116925:c596702-596367 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References