269444

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yafN-yafO (relBE)/YafO-YafN
Location 3721953..3722647 Replicon chromosome
Accession NZ_CP116923
Organism Escherichia coli strain MLI104K1

Toxin (Protein)


Gene name yafO Uniprot ID -
Locus tag NL419_RS19045 Protein ID WP_115223466.1
Coordinates 3721953..3722351 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name yafN Uniprot ID S1FJN6
Locus tag NL419_RS19050 Protein ID WP_000554757.1
Coordinates 3722354..3722647 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
- (3717613) 3717613..3717693 - 81 NuclAT_10 - -
- (3717613) 3717613..3717693 - 81 NuclAT_10 - -
- (3717613) 3717613..3717693 - 81 NuclAT_10 - -
- (3717613) 3717613..3717693 - 81 NuclAT_10 - -
NL419_RS19015 (3716953) 3716953..3718197 - 1245 WP_000189541.1 esterase FrsA -
NL419_RS19020 (3718289) 3718289..3718747 - 459 WP_001291990.1 xanthine phosphoribosyltransferase -
NL419_RS19025 (3719008) 3719008..3720465 + 1458 WP_001293003.1 cytosol nonspecific dipeptidase -
NL419_RS19030 (3720522) 3720522..3721043 - 522 Protein_3633 peptide chain release factor H -
NL419_RS19035 (3721042) 3721042..3721245 - 204 Protein_3634 RtcB family protein -
NL419_RS19040 (3721491) 3721491..3721943 - 453 WP_001059847.1 GNAT family N-acetyltransferase -
NL419_RS19045 (3721953) 3721953..3722351 - 399 WP_115223466.1 type II toxin-antitoxin system mRNA interferase toxin YafO Toxin
NL419_RS19050 (3722354) 3722354..3722647 - 294 WP_000554757.1 type I toxin-antitoxin system antitoxin YafN Antitoxin
NL419_RS19055 (3722699) 3722699..3723754 - 1056 WP_001226164.1 DNA polymerase IV -
NL419_RS19060 (3723825) 3723825..3724610 - 786 WP_000207587.1 putative lateral flagellar export/assembly protein LafU -
NL419_RS19065 (3724582) 3724582..3726294 + 1713 Protein_3640 flagellar biosynthesis protein FlhA -
NL419_RS19070 (3726518) 3726518..3727015 - 498 WP_072667535.1 REP-associated tyrosine transposase RayT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin YafO

(27-129)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15454.80 Da        Isoelectric Point: 8.0949

>T269444 WP_115223466.1 NZ_CP116923:c3722351-3721953 [Escherichia coli]
MRVFKTKLIRLQLTAEELDALTADFISYKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANVNNPFPPQLRQFSRT
NDEAHLVYCQGAFDEQAWLLIAILKPEPHKQARDNNQMHKIGKMAEAFRIRF

Download         Length: 399 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11233.81 Da        Isoelectric Point: 5.9050

>AT269444 WP_000554757.1 NZ_CP116923:c3722647-3722354 [Escherichia coli]
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKPIKARFRPSAARLEEITRRA
EKYLNDMTDDDFNDFKE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB S1FJN6

References