Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2450971..2451609 Replicon chromosome
Accession NZ_CP116923
Organism Escherichia coli strain MLI104K1

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag NL419_RS12420 Protein ID WP_000813794.1
Coordinates 2451433..2451609 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NL419_RS12415 Protein ID WP_001270286.1
Coordinates 2450971..2451387 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL419_RS12395 (2446123) 2446123..2447064 - 942 WP_001251304.1 ABC transporter permease -
NL419_RS12400 (2447065) 2447065..2448078 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
NL419_RS12405 (2448096) 2448096..2449241 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
NL419_RS12410 (2449486) 2449486..2450892 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
NL419_RS12415 (2450971) 2450971..2451387 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
NL419_RS12420 (2451433) 2451433..2451609 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
NL419_RS12425 (2451831) 2451831..2452061 + 231 WP_000494244.1 YncJ family protein -
NL419_RS12430 (2452153) 2452153..2454114 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
NL419_RS12435 (2454187) 2454187..2454723 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
NL419_RS12440 (2454815) 2454815..2455990 + 1176 WP_001236265.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 2456030..2457178 1148


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T269441 WP_000813794.1 NZ_CP116923:c2451609-2451433 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT269441 WP_001270286.1 NZ_CP116923:c2451387-2450971 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References