Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 717160..717853 Replicon chromosome
Accession NZ_CP116913
Organism Escherichia coli strain MLI023K1

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag NL406_RS04235 Protein ID WP_000415584.1
Coordinates 717160..717456 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag NL406_RS04240 Protein ID WP_000650107.1
Coordinates 717458..717853 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL406_RS04200 (712248) 712248..712562 - 315 WP_000958598.1 putative quinol monooxygenase -
NL406_RS04205 (712593) 712593..713174 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
NL406_RS04210 (713493) 713493..713825 + 333 WP_000917684.1 DUF2645 family protein -
NL406_RS04215 (713871) 713871..715220 - 1350 WP_187770307.1 quorum sensing histidine kinase QseC -
NL406_RS04220 (715217) 715217..715876 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
NL406_RS04225 (716028) 716028..716420 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
NL406_RS04230 (716473) 716473..716955 + 483 WP_000183505.1 GyrI-like domain-containing protein -
NL406_RS04235 (717160) 717160..717456 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
NL406_RS04240 (717458) 717458..717853 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
NL406_RS04245 (717986) 717986..719593 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
NL406_RS04250 (719731) 719731..721989 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T269382 WP_000415584.1 NZ_CP116913:717160-717456 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT269382 WP_000650107.1 NZ_CP116913:717458-717853 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References