Detailed information of TA system TA269373

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 770585..770923
• Replicon: chromosome
• Accession: NZ_CP116909
• Organism: Staphylococcus aureus strain AATYW

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A6B5C9Y4
• Locus tag: LOY12_RS03995
• Protein ID: WP_072357969.1
• Coordinates: 770585..770761 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	770749..770923 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LOY12_RS03975	765752..769534	+	3783	WP_016170804.1	phage tail spike protein	-
LOY12_RS03980	769527..769679	+	153	WP_001000058.1	hypothetical protein	-
LOY12_RS03985	769725..770012	+	288	WP_001262620.1	hypothetical protein	-
LOY12_RS03990	770068..770442	+	375	WP_000340977.1	hypothetical protein	-
LOY12_RS03995	770585..770761	+	177	WP_072357969.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	770749..770923	-	175	-	-	Antitoxin
LOY12_RS04005	770973..771227	+	255	WP_000611512.1	phage holin	-
LOY12_RS04010	771239..771994	+	756	WP_000861038.1	CHAP domain-containing protein	-
LOY12_RS04015	772185..772676	+	492	WP_000920041.1	staphylokinase	-
LOY12_RS04020	773327..773661	+	335	Protein_789	SH3 domain-containing protein	-
LOY12_RS04025	773754..774203	-	450	WP_000727645.1	chemotaxis-inhibiting protein CHIPS	-
LOY12_RS04030	774886..775236	+	351	WP_000702262.1	complement inhibitor SCIN-A	-
LOY12_RS04035	775289..775549	-	261	WP_001791826.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	groEL / hlb / sak / chp / scn	707711..775236	67525

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6863.47 Da
• Isoelectric Point: 10.6777

>T269373 WP_072357969.1 NZ_CP116909:770585-770761 [Staphylococcus aureus]
MDRWWLSEYKEVVPMLALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

Antitoxin

Nucleotide

• Length: 175 bp

>AT269373 NZ_CP116909:c770923-770749 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• AlphaFold DB: A0A6B5C9Y4

Antitoxin