Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 323800..324317 Replicon chromosome
Accession NZ_CP116909
Organism Staphylococcus aureus strain AATYW

Toxin (Protein)


Gene name yoeB Uniprot ID A0A3A3ATA4
Locus tag LOY12_RS01535 Protein ID WP_000113265.1
Coordinates 324051..324317 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag LOY12_RS01530 Protein ID WP_000584499.1
Coordinates 323800..324051 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOY12_RS01500 (319498) 319498..320217 + 720 WP_000479576.1 amino acid ABC transporter permease -
LOY12_RS01505 (320214) 320214..320945 + 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
LOY12_RS01510 (321042) 321042..322292 - 1251 WP_001012225.1 FemA/FemB family glycyltransferase FmhA -
LOY12_RS01515 (322547) 322547..322909 + 363 WP_000819843.1 DUF4467 domain-containing protein -
LOY12_RS01520 (322928) 322928..323527 + 600 WP_000162810.1 DsbA family protein -
LOY12_RS01525 (323555) 323555..323635 + 81 WP_223197974.1 hypothetical protein -
LOY12_RS01530 (323800) 323800..324051 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LOY12_RS01535 (324051) 324051..324317 + 267 WP_000113265.1 Txe/YoeB family addiction module toxin Toxin
LOY12_RS01540 (324352) 324352..324423 + 72 Protein_307 hypothetical protein -
LOY12_RS01545 (324612) 324612..326159 + 1548 WP_000727756.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
LOY12_RS01550 (326345) 326345..326812 + 468 WP_000153347.1 SRPBCC domain-containing protein -
LOY12_RS01555 (326896) 326896..327078 + 183 WP_000230292.1 hypothetical protein -
LOY12_RS01560 (327295) 327295..328119 + 825 WP_000572038.1 formate/nitrite transporter family protein -
LOY12_RS01565 (328353) 328353..328889 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-81)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10436.96 Da        Isoelectric Point: 10.0573

>T269366 WP_000113265.1 NZ_CP116909:324051-324317 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT269366 WP_000584499.1 NZ_CP116909:323800-324051 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BWF

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References