Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 2170714..2171407 Replicon chromosome
Accession NZ_CP116900
Organism Escherichia coli strain XH2172

Toxin (Protein)


Gene name mqsR Uniprot ID U9ZN09
Locus tag PH219_RS10420 Protein ID WP_000415585.1
Coordinates 2170714..2171010 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag PH219_RS10425 Protein ID WP_000650107.1
Coordinates 2171012..2171407 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PH219_RS10385 (2165848) 2165848..2166327 + 480 WP_000065332.1 Hcp family type VI secretion system effector -
PH219_RS10390 (2166330) 2166330..2167040 + 711 WP_000834030.1 hypothetical protein -
PH219_RS10395 (2167047) 2167047..2167379 + 333 WP_000914690.1 DUF2645 family protein -
PH219_RS10400 (2167425) 2167425..2168774 - 1350 WP_000673358.1 quorum sensing histidine kinase QseC -
PH219_RS10405 (2168771) 2168771..2169430 - 660 WP_001221502.1 quorum sensing response regulator transcription factor QseB -
PH219_RS10410 (2169582) 2169582..2169974 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
PH219_RS10415 (2170027) 2170027..2170509 + 483 WP_000183505.1 GyrI-like domain-containing protein -
PH219_RS10420 (2170714) 2170714..2171010 + 297 WP_000415585.1 type II toxin-antitoxin system toxin MqsR Toxin
PH219_RS10425 (2171012) 2171012..2171407 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
PH219_RS10430 (2171540) 2171540..2173147 + 1608 WP_001375094.1 ABC transporter substrate-binding protein -
PH219_RS10435 (2173285) 2173285..2175543 + 2259 WP_001281841.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(2-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11261.99 Da        Isoelectric Point: 8.9070

>T269316 WP_000415585.1 NZ_CP116900:2170714-2171010 [Escherichia coli]
MEKRTPHTRLSQVKKLVNTGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT269316 WP_000650107.1 NZ_CP116900:2171012-2171407 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9ZN09

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References