Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 470415..470929 Replicon chromosome
Accession NZ_CP116755
Organism Limosilactobacillus fermentum strain MWLf-4

Toxin (Protein)


Gene name yoeB Uniprot ID A0A806T892
Locus tag MWLf4_RS02280 Protein ID WP_021350110.1
Coordinates 470666..470929 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID C0WV67
Locus tag MWLf4_RS02275 Protein ID WP_003684069.1
Coordinates 470415..470669 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MWLf4_RS02260 (MWLf4_0466) 466787..468139 + 1353 WP_003684067.1 IS4 family transposase -
MWLf4_RS02265 (MWLf4_0467) 468702..469610 - 909 WP_251951731.1 IS3 family transposase -
MWLf4_RS02270 (MWLf4_0468) 469547..470245 - 699 Protein_436 transposase -
MWLf4_RS02275 (MWLf4_0469) 470415..470669 + 255 WP_003684069.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MWLf4_RS02280 (MWLf4_0470) 470666..470929 + 264 WP_021350110.1 Txe/YoeB family addiction module toxin Toxin
MWLf4_RS02285 (MWLf4_0471) 471335..472456 - 1122 WP_101889008.1 PTS sugar transporter subunit IIC -
MWLf4_RS02290 (MWLf4_0472) 472882..474279 - 1398 WP_187703846.1 Na+/H+ antiporter NhaC -
MWLf4_RS02295 (MWLf4_0473) 474667..475449 - 783 WP_021350113.1 arginine deiminase-related protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 438283..472456 34173


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-55)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10262.99 Da        Isoelectric Point: 10.7050

>T269225 WP_021350110.1 NZ_CP116755:470666-470929 [Limosilactobacillus fermentum]
MSYAIKLKRSANKDLKKIKGSYLEKSFLQIIEQLRKDPLAPNQGFEKLVPPIKGFYSRRINIQHRLVYKVDQDTQTVIIY
SAWSHNR

Download         Length: 264 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9745.04 Da        Isoelectric Point: 4.4237

>AT269225 WP_003684069.1 NZ_CP116755:470415-470669 [Limosilactobacillus fermentum]
MDQIVTPTQARKDLFKIIKRINENNEPVVIKPTKADEKSVVVIGEDDWKAIQETLFLVNHGVDKQIKERENEPLDDFDDV
WGQL

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A806T892

Antitoxin

Source ID Structure
AlphaFold DB A0A806T868

References