Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 204677..205313 Replicon chromosome
Accession NZ_CP116736
Organism Agrobacterium pusense strain CFBP5496

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag CFBP5496_RS16155 Protein ID WP_045533913.1
Coordinates 205032..205313 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag CFBP5496_RS16150 Protein ID WP_112766393.1
Coordinates 204677..204976 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFBP5496_RS16125 (CFBP5496_0016125) 199866..200594 - 729 WP_136883442.1 ABC transporter ATP-binding protein -
CFBP5496_RS16130 (CFBP5496_0016130) 200591..201499 - 909 WP_136883441.1 branched-chain amino acid ABC transporter permease -
CFBP5496_RS16135 (CFBP5496_0016135) 201496..202368 - 873 WP_112637286.1 branched-chain amino acid ABC transporter permease -
CFBP5496_RS16140 (CFBP5496_0016140) 202438..203652 - 1215 WP_136883440.1 amino acid ABC transporter substrate-binding protein -
CFBP5496_RS16145 (CFBP5496_0016145) 203785..204657 + 873 WP_136883439.1 AraC family transcriptional regulator -
CFBP5496_RS16150 (CFBP5496_0016150) 204677..204976 - 300 WP_112766393.1 HigA family addiction module antitoxin Antitoxin
CFBP5496_RS16155 (CFBP5496_0016155) 205032..205313 - 282 WP_045533913.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CFBP5496_RS16160 (CFBP5496_0016160) 205375..206196 - 822 WP_136883438.1 ABC transporter ATP-binding protein -
CFBP5496_RS16165 (CFBP5496_0016165) 206193..207227 - 1035 WP_136883437.1 iron chelate uptake ABC transporter family permease subunit -
CFBP5496_RS16170 (CFBP5496_0016170) 207230..208273 - 1044 WP_136883436.1 iron ABC transporter permease -
CFBP5496_RS16175 (CFBP5496_0016175) 208270..209277 - 1008 WP_136883435.1 iron-siderophore ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - katB 193929..265869 71940


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(4-97)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10610.04 Da        Isoelectric Point: 9.0298

>T269223 WP_045533913.1 NZ_CP116736:c205313-205032 [Agrobacterium pusense]
MIRSFKNKLTASIDDGSVKKGFPSDMLRRAQQLLTVLDAATTVEDLRSPPGNRLEKLSGDREGQYSIRINKQWRICFVWT
QAGPENVEITDYH

Download         Length: 282 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11090.89 Da        Isoelectric Point: 8.5148

>AT269223 WP_112766393.1 NZ_CP116736:c204976-204677 [Agrobacterium pusense]
MTISKSPPIHPGEILRELYLEPLGMSAYALARHLNVPRTRIERIAGEKLGITADTALRLAKFFKTTPEYWLNLQNAFDIK
AAATRLETDLANIKELEAA

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References