Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 6000793..6001388 Replicon chromosome
Accession NZ_CP116725
Organism Pseudomonas aeruginosa strain 2881

Toxin (Protein)


Gene name higB Uniprot ID A0A241XLJ5
Locus tag PMJ88_RS28430 Protein ID WP_003117425.1
Coordinates 6001110..6001388 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PMJ88_RS28425 Protein ID WP_003099268.1
Coordinates 6000793..6001098 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PMJ88_RS28395 (PMJ88_28395) 5997436..5997711 - 276 WP_033896065.1 mercury resistance system periplasmic binding protein MerP -
PMJ88_RS28400 (PMJ88_28400) 5997727..5998077 - 351 WP_001294660.1 mercuric transport protein MerT -
PMJ88_RS28405 (PMJ88_28405) 5998149..5998604 + 456 WP_033896066.1 Hg(II)-responsive transcriptional regulator -
PMJ88_RS28410 (PMJ88_28410) 5998966..5999880 - 915 WP_227495466.1 hypothetical protein -
PMJ88_RS28415 (PMJ88_28415) 5999919..6000131 - 213 WP_025297679.1 AlpA family phage regulatory protein -
PMJ88_RS28425 (PMJ88_28425) 6000793..6001098 - 306 WP_003099268.1 HigA family addiction module antitoxin Antitoxin
PMJ88_RS28430 (PMJ88_28430) 6001110..6001388 - 279 WP_003117425.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PMJ88_RS28435 (PMJ88_28435) 6001441..6001565 - 125 Protein_5625 integrase -
PMJ88_RS28440 (PMJ88_28440) 6001713..6003941 + 2229 WP_003113525.1 TonB-dependent receptor -
PMJ88_RS28445 (PMJ88_28445) 6004011..6004658 - 648 WP_003095021.1 carbonate dehydratase -
PMJ88_RS28450 (PMJ88_28450) 6004720..6005958 - 1239 WP_014603324.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10701.28 Da        Isoelectric Point: 8.5576

>T269210 WP_003117425.1 NZ_CP116725:c6001388-6001110 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAARELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11213.79 Da        Isoelectric Point: 5.0747

>AT269210 WP_003099268.1 NZ_CP116725:c6001098-6000793 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A241XLJ5

Antitoxin

Source ID Structure

References