269201

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 6051434..6052029 Replicon chromosome
Accession NZ_CP116724
Organism Pseudomonas aeruginosa strain 2880

Toxin (Protein)


Gene name higB Uniprot ID A0A241XLJ5
Locus tag PMJ92_RS28715 Protein ID WP_003117425.1
Coordinates 6051751..6052029 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PMJ92_RS28710 Protein ID WP_003099268.1
Coordinates 6051434..6051739 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PMJ92_RS28675 (PMJ92_28675) 6046657..6046908 - 252 WP_003115979.1 hypothetical protein -
PMJ92_RS28680 (PMJ92_28680) 6047030..6047464 - 435 WP_023087663.1 hypothetical protein -
PMJ92_RS28685 (PMJ92_28685) 6047980..6048270 - 291 WP_033896069.1 DUF5447 family protein -
PMJ92_RS28690 (PMJ92_28690) 6048446..6048718 - 273 WP_004352675.1 hypothetical protein -
PMJ92_RS28695 (PMJ92_28695) 6049165..6049500 + 336 WP_025297674.1 hypothetical protein -
PMJ92_RS28700 (PMJ92_28700) 6049553..6050644 + 1092 WP_124135598.1 hypothetical protein -
PMJ92_RS28705 (PMJ92_28705) 6050705..6051097 - 393 WP_025297673.1 hypothetical protein -
PMJ92_RS28710 (PMJ92_28710) 6051434..6051739 - 306 WP_003099268.1 HigA family addiction module antitoxin Antitoxin
PMJ92_RS28715 (PMJ92_28715) 6051751..6052029 - 279 WP_003117425.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PMJ92_RS28720 (PMJ92_28720) 6052354..6054582 + 2229 WP_003113525.1 TonB-dependent receptor -
PMJ92_RS28725 (PMJ92_28725) 6054652..6055299 - 648 WP_003095021.1 carbonate dehydratase -
PMJ92_RS28730 (PMJ92_28730) 6055361..6056599 - 1239 WP_014603324.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10701.28 Da        Isoelectric Point: 8.5576

>T269201 WP_003117425.1 NZ_CP116724:c6052029-6051751 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAARELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11213.79 Da        Isoelectric Point: 5.0747

>AT269201 WP_003099268.1 NZ_CP116724:c6051739-6051434 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A241XLJ5

Antitoxin

Source ID Structure

References