Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 6170849..6171444 Replicon chromosome
Accession NZ_CP116722
Organism Pseudomonas aeruginosa strain 2868

Toxin (Protein)


Gene name higB Uniprot ID A0A241XLJ5
Locus tag PMJ90_RS29460 Protein ID WP_003117425.1
Coordinates 6171166..6171444 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PMJ90_RS29455 Protein ID WP_003099268.1
Coordinates 6170849..6171154 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PMJ90_RS29420 (PMJ90_29420) 6166072..6166323 - 252 WP_003115979.1 hypothetical protein -
PMJ90_RS29425 (PMJ90_29425) 6166445..6166879 - 435 WP_023087663.1 hypothetical protein -
PMJ90_RS29430 (PMJ90_29430) 6167395..6167685 - 291 WP_033896069.1 DUF5447 family protein -
PMJ90_RS29435 (PMJ90_29435) 6167861..6168133 - 273 WP_004352675.1 hypothetical protein -
PMJ90_RS29440 (PMJ90_29440) 6168580..6168915 + 336 WP_025297674.1 hypothetical protein -
PMJ90_RS29445 (PMJ90_29445) 6168968..6170059 + 1092 WP_124135598.1 hypothetical protein -
PMJ90_RS29450 (PMJ90_29450) 6170120..6170512 - 393 WP_025297673.1 hypothetical protein -
PMJ90_RS29455 (PMJ90_29455) 6170849..6171154 - 306 WP_003099268.1 HigA family addiction module antitoxin Antitoxin
PMJ90_RS29460 (PMJ90_29460) 6171166..6171444 - 279 WP_003117425.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PMJ90_RS29465 (PMJ90_29465) 6171769..6173997 + 2229 WP_003113525.1 TonB-dependent receptor -
PMJ90_RS29470 (PMJ90_29470) 6174067..6174714 - 648 WP_003095021.1 carbonate dehydratase -
PMJ90_RS29475 (PMJ90_29475) 6174776..6176014 - 1239 WP_014603324.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10701.28 Da        Isoelectric Point: 8.5576

>T269193 WP_003117425.1 NZ_CP116722:c6171444-6171166 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAARELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11213.79 Da        Isoelectric Point: 5.0747

>AT269193 WP_003099268.1 NZ_CP116722:c6171154-6170849 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A241XLJ5

Antitoxin

Source ID Structure

References