Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 6023119..6023714 Replicon chromosome
Accession NZ_CP116721
Organism Pseudomonas aeruginosa strain 2867

Toxin (Protein)


Gene name higB Uniprot ID A0A241XLJ5
Locus tag PMJ93_RS28460 Protein ID WP_003117425.1
Coordinates 6023436..6023714 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PMJ93_RS28455 Protein ID WP_003099268.1
Coordinates 6023119..6023424 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PMJ93_RS28420 (PMJ93_28420) 6018342..6018593 - 252 WP_003115979.1 hypothetical protein -
PMJ93_RS28425 (PMJ93_28425) 6018715..6019149 - 435 WP_023087663.1 hypothetical protein -
PMJ93_RS28430 (PMJ93_28430) 6019665..6019955 - 291 WP_033896069.1 DUF5447 family protein -
PMJ93_RS28435 (PMJ93_28435) 6020131..6020403 - 273 WP_004352675.1 hypothetical protein -
PMJ93_RS28440 (PMJ93_28440) 6020850..6021185 + 336 WP_025297674.1 hypothetical protein -
PMJ93_RS28445 (PMJ93_28445) 6021238..6022329 + 1092 WP_124135598.1 hypothetical protein -
PMJ93_RS28450 (PMJ93_28450) 6022390..6022782 - 393 WP_025297673.1 hypothetical protein -
PMJ93_RS28455 (PMJ93_28455) 6023119..6023424 - 306 WP_003099268.1 HigA family addiction module antitoxin Antitoxin
PMJ93_RS28460 (PMJ93_28460) 6023436..6023714 - 279 WP_003117425.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PMJ93_RS28465 (PMJ93_28465) 6024039..6026267 + 2229 WP_003113525.1 TonB-dependent receptor -
PMJ93_RS28470 (PMJ93_28470) 6026337..6026984 - 648 WP_003095021.1 carbonate dehydratase -
PMJ93_RS28475 (PMJ93_28475) 6027046..6028284 - 1239 WP_014603324.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10701.28 Da        Isoelectric Point: 8.5576

>T269186 WP_003117425.1 NZ_CP116721:c6023714-6023436 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAARELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11213.79 Da        Isoelectric Point: 5.0747

>AT269186 WP_003099268.1 NZ_CP116721:c6023424-6023119 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A241XLJ5

Antitoxin

Source ID Structure

References