Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5987138..5987733 Replicon chromosome
Accession NZ_CP116720
Organism Pseudomonas aeruginosa strain 2866

Toxin (Protein)


Gene name higB Uniprot ID A0A241XLJ5
Locus tag PMJ84_RS28390 Protein ID WP_003117425.1
Coordinates 5987455..5987733 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PMJ84_RS28385 Protein ID WP_003099268.1
Coordinates 5987138..5987443 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PMJ84_RS28350 (PMJ84_28350) 5982361..5982612 - 252 WP_003115979.1 hypothetical protein -
PMJ84_RS28355 (PMJ84_28355) 5982734..5983168 - 435 WP_023087663.1 hypothetical protein -
PMJ84_RS28360 (PMJ84_28360) 5983684..5983974 - 291 WP_033896069.1 DUF5447 family protein -
PMJ84_RS28365 (PMJ84_28365) 5984150..5984422 - 273 WP_004352675.1 hypothetical protein -
PMJ84_RS28370 (PMJ84_28370) 5984869..5985204 + 336 WP_025297674.1 hypothetical protein -
PMJ84_RS28375 (PMJ84_28375) 5985257..5986348 + 1092 WP_124135598.1 hypothetical protein -
PMJ84_RS28380 (PMJ84_28380) 5986409..5986801 - 393 WP_025297673.1 hypothetical protein -
PMJ84_RS28385 (PMJ84_28385) 5987138..5987443 - 306 WP_003099268.1 HigA family addiction module antitoxin Antitoxin
PMJ84_RS28390 (PMJ84_28390) 5987455..5987733 - 279 WP_003117425.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PMJ84_RS28395 (PMJ84_28395) 5988058..5990286 + 2229 WP_003113525.1 TonB-dependent receptor -
PMJ84_RS28400 (PMJ84_28400) 5990356..5991003 - 648 WP_003095021.1 carbonate dehydratase -
PMJ84_RS28405 (PMJ84_28405) 5991065..5992303 - 1239 WP_014603324.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10701.28 Da        Isoelectric Point: 8.5576

>T269178 WP_003117425.1 NZ_CP116720:c5987733-5987455 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAARELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11213.79 Da        Isoelectric Point: 5.0747

>AT269178 WP_003099268.1 NZ_CP116720:c5987443-5987138 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A241XLJ5

Antitoxin

Source ID Structure

References