Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5908014..5908609 Replicon chromosome
Accession NZ_CP116718
Organism Pseudomonas aeruginosa strain 2858

Toxin (Protein)


Gene name higB Uniprot ID A0A241XLJ5
Locus tag PMJ85_RS27905 Protein ID WP_003117425.1
Coordinates 5908331..5908609 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PMJ85_RS27900 Protein ID WP_003099268.1
Coordinates 5908014..5908319 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PMJ85_RS27865 (PMJ85_27865) 5903237..5903488 - 252 WP_003115979.1 hypothetical protein -
PMJ85_RS27870 (PMJ85_27870) 5903610..5904044 - 435 WP_023087663.1 hypothetical protein -
PMJ85_RS27875 (PMJ85_27875) 5904560..5904850 - 291 WP_033896069.1 DUF5447 family protein -
PMJ85_RS27880 (PMJ85_27880) 5905026..5905298 - 273 WP_004352675.1 hypothetical protein -
PMJ85_RS27885 (PMJ85_27885) 5905745..5906080 + 336 WP_025297674.1 hypothetical protein -
PMJ85_RS27890 (PMJ85_27890) 5906133..5907224 + 1092 WP_124135598.1 hypothetical protein -
PMJ85_RS27895 (PMJ85_27895) 5907285..5907677 - 393 WP_025297673.1 hypothetical protein -
PMJ85_RS27900 (PMJ85_27900) 5908014..5908319 - 306 WP_003099268.1 HigA family addiction module antitoxin Antitoxin
PMJ85_RS27905 (PMJ85_27905) 5908331..5908609 - 279 WP_003117425.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PMJ85_RS27910 (PMJ85_27910) 5908934..5911162 + 2229 WP_003113525.1 TonB-dependent receptor -
PMJ85_RS27915 (PMJ85_27915) 5911232..5911879 - 648 WP_003095021.1 carbonate dehydratase -
PMJ85_RS27920 (PMJ85_27920) 5911941..5913179 - 1239 WP_014603324.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10701.28 Da        Isoelectric Point: 8.5576

>T269170 WP_003117425.1 NZ_CP116718:c5908609-5908331 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAARELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11213.79 Da        Isoelectric Point: 5.0747

>AT269170 WP_003099268.1 NZ_CP116718:c5908319-5908014 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A241XLJ5

Antitoxin

Source ID Structure

References