Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 6069321..6069916 Replicon chromosome
Accession NZ_CP116717
Organism Pseudomonas aeruginosa strain 2857

Toxin (Protein)


Gene name higB Uniprot ID A0A241XLJ5
Locus tag PMJ94_RS28810 Protein ID WP_003117425.1
Coordinates 6069638..6069916 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PMJ94_RS28805 Protein ID WP_003099268.1
Coordinates 6069321..6069626 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PMJ94_RS28775 (PMJ94_28775) 6065964..6066239 - 276 WP_033896065.1 mercury resistance system periplasmic binding protein MerP -
PMJ94_RS28780 (PMJ94_28780) 6066255..6066605 - 351 WP_001294660.1 mercuric transport protein MerT -
PMJ94_RS28785 (PMJ94_28785) 6066677..6067132 + 456 WP_033896066.1 Hg(II)-responsive transcriptional regulator -
PMJ94_RS28790 (PMJ94_28790) 6067494..6068408 - 915 WP_227495466.1 hypothetical protein -
PMJ94_RS28795 (PMJ94_28795) 6068447..6068659 - 213 WP_025297679.1 AlpA family phage regulatory protein -
PMJ94_RS28805 (PMJ94_28805) 6069321..6069626 - 306 WP_003099268.1 HigA family addiction module antitoxin Antitoxin
PMJ94_RS28810 (PMJ94_28810) 6069638..6069916 - 279 WP_003117425.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PMJ94_RS28815 (PMJ94_28815) 6069969..6070093 - 125 Protein_5700 integrase -
PMJ94_RS28820 (PMJ94_28820) 6070241..6072469 + 2229 WP_272225935.1 TonB-dependent receptor -
PMJ94_RS28825 (PMJ94_28825) 6072539..6073186 - 648 WP_003095021.1 carbonate dehydratase -
PMJ94_RS28830 (PMJ94_28830) 6073248..6074486 - 1239 WP_014603324.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10701.28 Da        Isoelectric Point: 8.5576

>T269162 WP_003117425.1 NZ_CP116717:c6069916-6069638 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAARELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11213.79 Da        Isoelectric Point: 5.0747

>AT269162 WP_003099268.1 NZ_CP116717:c6069626-6069321 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A241XLJ5

Antitoxin

Source ID Structure

References