Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5979559..5980154 Replicon chromosome
Accession NZ_CP116715
Organism Pseudomonas aeruginosa strain 2856

Toxin (Protein)


Gene name higB Uniprot ID A0A241XLJ5
Locus tag PMJ91_RS28590 Protein ID WP_003117425.1
Coordinates 5979876..5980154 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PMJ91_RS28585 Protein ID WP_003099268.1
Coordinates 5979559..5979864 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PMJ91_RS28555 (PMJ91_28555) 5976202..5976477 - 276 WP_033896065.1 mercury resistance system periplasmic binding protein MerP -
PMJ91_RS28560 (PMJ91_28560) 5976493..5976843 - 351 WP_001294660.1 mercuric transport protein MerT -
PMJ91_RS28565 (PMJ91_28565) 5976915..5977370 + 456 WP_033896066.1 Hg(II)-responsive transcriptional regulator -
PMJ91_RS28570 (PMJ91_28570) 5977732..5978646 - 915 WP_227495466.1 hypothetical protein -
PMJ91_RS28575 (PMJ91_28575) 5978685..5978897 - 213 WP_025297679.1 AlpA family phage regulatory protein -
PMJ91_RS28585 (PMJ91_28585) 5979559..5979864 - 306 WP_003099268.1 HigA family addiction module antitoxin Antitoxin
PMJ91_RS28590 (PMJ91_28590) 5979876..5980154 - 279 WP_003117425.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PMJ91_RS28595 (PMJ91_28595) 5980207..5980331 - 125 Protein_5655 integrase -
PMJ91_RS28600 (PMJ91_28600) 5980479..5982707 + 2229 WP_003113525.1 TonB-dependent receptor -
PMJ91_RS28605 (PMJ91_28605) 5982777..5983424 - 648 WP_003095021.1 carbonate dehydratase -
PMJ91_RS28610 (PMJ91_28610) 5983486..5984724 - 1239 WP_014603324.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10701.28 Da        Isoelectric Point: 8.5576

>T269155 WP_003117425.1 NZ_CP116715:c5980154-5979876 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAARELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11213.79 Da        Isoelectric Point: 5.0747

>AT269155 WP_003099268.1 NZ_CP116715:c5979864-5979559 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A241XLJ5

Antitoxin

Source ID Structure

References