Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5759236..5759831 Replicon chromosome
Accession NZ_CP116682
Organism Pseudomonas aeruginosa strain HS337

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag OK431_RS27505 Protein ID WP_003113526.1
Coordinates 5759553..5759831 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OK431_RS27500 Protein ID WP_003113527.1
Coordinates 5759236..5759541 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OK431_RS27480 (OK431_27465) 5755312..5755569 + 258 WP_010793759.1 ATP-binding protein -
OK431_RS27485 (OK431_27470) 5755945..5756808 - 864 WP_010793758.1 integrase domain-containing protein -
OK431_RS27490 (OK431_27475) 5757410..5758552 - 1143 WP_010793757.1 STY4528 family pathogenicity island replication protein -
OK431_RS27500 (OK431_27485) 5759236..5759541 - 306 WP_003113527.1 HigA family addiction module antitoxin Antitoxin
OK431_RS27505 (OK431_27490) 5759553..5759831 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OK431_RS27510 (OK431_27495) 5759884..5760012 - 129 Protein_5438 integrase -
OK431_RS27515 (OK431_27500) 5760160..5762388 + 2229 WP_003099265.1 TonB-dependent receptor -
OK431_RS27520 (OK431_27505) 5762458..5763105 - 648 WP_003095021.1 carbonate dehydratase -
OK431_RS27525 (OK431_27510) 5763167..5764405 - 1239 WP_010793756.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T269118 WP_003113526.1 NZ_CP116682:c5759831-5759553 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11247.81 Da        Isoelectric Point: 5.0747

>AT269118 WP_003113527.1 NZ_CP116682:c5759541-5759236 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMEFDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References