269077

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 1743925..1745185 Replicon chromosome
Accession NZ_CP116614
Organism Porphyromonas gingivalis strain ATCC 49417

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag NY151_RS07645 Protein ID WP_077084040.1
Coordinates 1743925..1744860 (-) Length 312 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID -
Locus tag NY151_RS07650 Protein ID WP_077084039.1
Coordinates 1744850..1745185 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NY151_RS07630 (NY151_07630) 1739479..1740795 - 1317 WP_077084043.1 restriction endonuclease subunit S -
NY151_RS07635 (NY151_07635) 1740808..1742847 - 2040 WP_077084042.1 class I SAM-dependent DNA methyltransferase -
NY151_RS07640 (NY151_07640) 1742909..1743910 - 1002 WP_077084041.1 WYL domain-containing protein -
NY151_RS07645 (NY151_07645) 1743925..1744860 - 936 WP_077084040.1 HipA domain-containing protein Toxin
NY151_RS07650 (NY151_07650) 1744850..1745185 - 336 WP_077084039.1 HipA N-terminal domain-containing protein Antitoxin
NY151_RS07655 (NY151_07655) 1745182..1745406 - 225 WP_077084038.1 helix-turn-helix transcriptional regulator -
NY151_RS07660 (NY151_07660) 1745548..1745811 - 264 Protein_1492 type II toxin-antitoxin system HipA family toxin -
NY151_RS07665 (NY151_07665) 1745851..1746939 + 1089 Protein_1493 ISAs1 family transposase -
NY151_RS07670 (NY151_07670) 1746951..1747955 - 1005 Protein_1494 HipA domain-containing protein -
NY151_RS07675 (NY151_07675) 1747959..1748279 - 321 WP_039431927.1 helix-turn-helix transcriptional regulator -
NY151_RS07680 (NY151_07680) 1748674..1749456 - 783 WP_004584112.1 DUF4393 domain-containing protein -
NY151_RS07685 (NY151_07685) 1749493..1749750 - 258 WP_271935194.1 histidinol phosphate phosphatase -
NY151_RS07690 (NY151_07690) 1749684..1749977 - 294 WP_271935813.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-277)

Antitoxin

HipA, N-terminal subdomain 1

(6-101)


Sequences

Toxin        


Download         Length: 312 a.a.        Molecular weight: 35992.42 Da        Isoelectric Point: 6.1764

>T269077 WP_077084040.1 NZ_CP116614:c1744860-1743925 [Porphyromonas gingivalis]
MTNRCLYCYEPLVDGEVDYHAKCCRKLFGTNQAPILPYTSNEVRALADEVVRSQTTVTGVQPKLSLDFDQMSHSPKRFTI
VGLWGRFILKPQTEHYPHLPELEDVSMHLAEIAKIETVPHGLMRFSDGELCYITRRIDRTGQGEKLPMEDMCQLSERLTE
YKYKGSHEQIAKLISKYSSVPKLDLIKYWEQVLFSWLIGNADMHLKNYSLYAPIGNEYQLTPAYDLLSTALVIPEDTEEL
ALPLCGKKRKLTRQHFLEAMIASGLEEKVCDNIFTRFGRILPEWEACIHQSFLPQEMQEQYIELISYRSNK

Download         Length: 936 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12646.49 Da        Isoelectric Point: 4.3108

>AT269077 WP_077084039.1 NZ_CP116614:c1745185-1744850 [Porphyromonas gingivalis]
MKQAIVYWKSLKAGILTESDEGYSFAYDKDYLTMPEVQGISLTMPLREEPFQSNTLHPFFDGLIPEGWLLDIAQKNWKID
ARDRMALLLACCRDCIGAVSIKPLNTTEDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References