Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 1241940..1243203 Replicon chromosome
Accession NZ_CP116612
Organism Porphyromonas gingivalis strain A7436-C

Toxin (Protein)


Gene name HipT Uniprot ID Q7MW07
Locus tag NY148_RS05325 Protein ID WP_010956143.1
Coordinates 1241940..1242878 (-) Length 313 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID Q7MW08
Locus tag NY148_RS05330 Protein ID WP_005874041.1
Coordinates 1242868..1243203 (-) Length 112 a.a.

Genomic Context

NY148_RS05315NY148_RS05320NY148_RS05325NY148_RS05330NY148_RS05335NY148_RS05340NY148_RS05345NY148_RS05350NY148_RS05355NY148_RS05360
Location: 1238014..1241496 (3483 bp)
Type: Others
Protein ID: WP_005874047.1
Location: 1241550..1241870 (321 bp)
Type: Others
Protein ID: WP_043876418.1
Location: 1241940..1242878 (939 bp)
Type: Toxin
Protein ID: WP_010956143.1
Location: 1242868..1243203 (336 bp)
Type: Antitoxin
Protein ID: WP_005874041.1
Location: 1243200..1243424 (225 bp)
Type: Others
Protein ID: WP_005874043.1
Location: 1243648..1244553 (906 bp)
Type: Others
Protein ID: WP_005874039.1
Location: 1245055..1245837 (783 bp)
Type: Others
Protein ID: WP_004584112.1
Location: 1245874..1246359 (486 bp)
Type: Others
Protein ID: WP_005874045.1
Location: 1246594..1246764 (171 bp)
Type: Others
Protein ID: WP_080502141.1
Location: 1246789..1247870 (1082 bp)
Type: Others
Protein ID: Protein_1036
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
NY148_RS05315 (NY148_05315)1238014..1241496-3483WP_005874047.1helicase-related protein-
NY148_RS05320 (NY148_05320)1241550..1241870-321WP_043876418.1helix-turn-helix transcriptional regulator-
NY148_RS05325 (NY148_05325)1241940..1242878-939WP_010956143.1HipA domain-containing proteinToxin
NY148_RS05330 (NY148_05330)1242868..1243203-336WP_005874041.1HipA N-terminal domain-containing proteinAntitoxin
NY148_RS05335 (NY148_05335)1243200..1243424-225WP_005874043.1helix-turn-helix transcriptional regulator-
NY148_RS05340 (NY148_05340)1243648..1244553-906WP_005874039.1hypothetical protein-
NY148_RS05345 (NY148_05345)1245055..1245837-783WP_004584112.1DUF4393 domain-containing protein-
NY148_RS05350 (NY148_05350)1245874..1246359-486WP_005874045.1HU family DNA-binding protein-
NY148_RS05355 (NY148_05355)1246594..1246764-171WP_080502141.1DNA methylase-
NY148_RS05360 (NY148_05360)1246789..1247870-1082Protein_1036IS5 family transposase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-280)

Antitoxin

HipA, N-terminal subdomain 1

(6-101)


Sequences

Toxin        


Download         Length: 313 a.a.        Molecular weight: 36101.60 Da        Isoelectric Point: 6.1022

>T269076 WP_010956143.1 NZ_CP116612:c1242878-1241940 [Porphyromonas gingivalis]
MTNRCLYCYEPLVDGEMDYHAKCCRKLFGTPQAPILPYTSSEVRALADEVVRSQTTVTGVQPKLSLDFDQMSNSPKRFTI
VGLWGRFILKPQTERYSHLPELEDVSMHLAEIAKIETVPHGLMRFSDGELCYITRRIDRTGQGEKLPMEDMCQLSERLTE
YKYKGSHEQVAKLISKYSSVPKLDLVKYWEQVLFSWLIGNADMHLKNYSLYAPEGNEYQLTPAYDLLSTALVIPEDTEEL
ALTLCGKKRKLTRQHFLEAMTASGLDEKVCDNIFARFQHILPEWEACIRQSFLPTEMQRQYIEFILLKFSQI

Download         Length: 939 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12679.49 Da        Isoelectric Point: 4.1551

>AT269076 WP_005874041.1 NZ_CP116612:c1243203-1242868 [Porphyromonas gingivalis]
MKQAIVYWKTLKAGILTESDEGYSFAYDKDYLTMPEAQGISLTMPLREEPFQSNMLHPFFDGLIPEGWLLDIAQKNWKID
SRDRMALLLACCRDCIGAVSIEPLNTTEDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ7MW07

Antitoxin

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Source
ID
Structure
AlphaFold DBQ7MW08

References