269076

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 1241940..1243203 Replicon chromosome
Accession NZ_CP116612
Organism Porphyromonas gingivalis strain A7436-C

Toxin (Protein)


Gene name HipT Uniprot ID Q7MW07
Locus tag NY148_RS05325 Protein ID WP_010956143.1
Coordinates 1241940..1242878 (-) Length 313 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID Q7MW08
Locus tag NY148_RS05330 Protein ID WP_005874041.1
Coordinates 1242868..1243203 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NY148_RS05315 (NY148_05315) 1238014..1241496 - 3483 WP_005874047.1 helicase-related protein -
NY148_RS05320 (NY148_05320) 1241550..1241870 - 321 WP_043876418.1 helix-turn-helix transcriptional regulator -
NY148_RS05325 (NY148_05325) 1241940..1242878 - 939 WP_010956143.1 HipA domain-containing protein Toxin
NY148_RS05330 (NY148_05330) 1242868..1243203 - 336 WP_005874041.1 HipA N-terminal domain-containing protein Antitoxin
NY148_RS05335 (NY148_05335) 1243200..1243424 - 225 WP_005874043.1 helix-turn-helix transcriptional regulator -
NY148_RS05340 (NY148_05340) 1243648..1244553 - 906 WP_005874039.1 hypothetical protein -
NY148_RS05345 (NY148_05345) 1245055..1245837 - 783 WP_004584112.1 DUF4393 domain-containing protein -
NY148_RS05350 (NY148_05350) 1245874..1246359 - 486 WP_005874045.1 HU family DNA-binding protein -
NY148_RS05355 (NY148_05355) 1246594..1246764 - 171 WP_080502141.1 DNA methylase -
NY148_RS05360 (NY148_05360) 1246789..1247870 - 1082 Protein_1036 IS5 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-280)

Antitoxin

HipA, N-terminal subdomain 1

(6-101)


Sequences

Toxin        


Download         Length: 313 a.a.        Molecular weight: 36101.60 Da        Isoelectric Point: 6.1022

>T269076 WP_010956143.1 NZ_CP116612:c1242878-1241940 [Porphyromonas gingivalis]
MTNRCLYCYEPLVDGEMDYHAKCCRKLFGTPQAPILPYTSSEVRALADEVVRSQTTVTGVQPKLSLDFDQMSNSPKRFTI
VGLWGRFILKPQTERYSHLPELEDVSMHLAEIAKIETVPHGLMRFSDGELCYITRRIDRTGQGEKLPMEDMCQLSERLTE
YKYKGSHEQVAKLISKYSSVPKLDLVKYWEQVLFSWLIGNADMHLKNYSLYAPEGNEYQLTPAYDLLSTALVIPEDTEEL
ALTLCGKKRKLTRQHFLEAMTASGLDEKVCDNIFARFQHILPEWEACIRQSFLPTEMQRQYIEFILLKFSQI

Download         Length: 939 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12679.49 Da        Isoelectric Point: 4.1551

>AT269076 WP_005874041.1 NZ_CP116612:c1243203-1242868 [Porphyromonas gingivalis]
MKQAIVYWKTLKAGILTESDEGYSFAYDKDYLTMPEAQGISLTMPLREEPFQSNMLHPFFDGLIPEGWLLDIAQKNWKID
SRDRMALLLACCRDCIGAVSIEPLNTTEDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q7MW07

Antitoxin

Source ID Structure
AlphaFold DB Q7MW08

References