Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2668119..2668382 Replicon chromosome
Accession NZ_CP116575
Organism Enterococcus faecalis strain K205-3

Toxin (Protein)


Gene name txpA Uniprot ID S4BYM2
Locus tag PML83_RS13125 Protein ID WP_002392696.1
Coordinates 2668239..2668382 (-) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2668119..2668306 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PML83_RS13110 2663485..2664198 - 714 WP_002381063.1 trehalose operon repressor -
PML83_RS13115 2664460..2667204 + 2745 WP_002398920.1 glycosyl hydrolase family 65 protein -
PML83_RS13120 2667219..2667869 + 651 WP_002354875.1 beta-phosphoglucomutase -
- 2668119..2668306 + 188 - - Antitoxin
PML83_RS13125 2668239..2668382 - 144 WP_002392696.1 type I toxin-antitoxin system toxin PepG1 Toxin
PML83_RS13130 2669456..2669731 + 276 WP_224805966.1 CPBP family intramembrane metalloprotease -
PML83_RS13135 2669785..2670756 - 972 WP_002381060.1 ribose-phosphate diphosphokinase -
PML83_RS13140 2670931..2671368 - 438 WP_002354871.1 peptide-methionine (R)-S-oxide reductase MsrB -
PML83_RS13145 2671501..2672055 - 555 WP_002354869.1 Maf family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5297.43 Da        Isoelectric Point: 10.6867

>T269031 WP_002392696.1 NZ_CP116575:c2668382-2668239 [Enterococcus faecalis]
MSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Download         Length: 144 bp

Antitoxin


Download         Length: 188 bp

>AT269031 NZ_CP116575:2668119-2668306 [Enterococcus faecalis]
TGTGCTATAATGAAAATGAAAAGAGAGATATGCTTCAACATACCTCTCTGATGTAGAGCCGTTTAAGACGGTGACTTTTT
GAATTATTTAAAAATAACCGTACTCGGTCAAAGTTGACGGTTATTTTTTATTGTCATTTTTAAGCAATTTCACAATCAGT
GCAATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S4BYM2

Antitoxin

Download structure file

References