Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2827740..2828066 Replicon chromosome
Accession NZ_CP116571
Organism Enterococcus faecalis strain K190-1

Toxin (Protein)


Gene name txpA Uniprot ID A0A3N3Z2N6
Locus tag PML73_RS13970 Protein ID WP_073340360.1
Coordinates 2827926..2828066 (+) Length 47 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2827740..2827924 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PML73_RS13945 2822779..2822994 - 216 WP_002354768.1 zinc ribbon domain-containing protein -
PML73_RS13950 2823133..2824125 + 993 WP_002389493.1 biotin--[acetyl-CoA-carboxylase] ligase -
PML73_RS13955 2824389..2825027 - 639 WP_271865427.1 lytic polysaccharide monooxygenase -
PML73_RS13960 2825713..2827329 + 1617 WP_002389442.1 phosphatase PAP2/LCP family protein -
PML73_RS13965 2827658..2827807 + 150 WP_002411240.1 type I toxin-antitoxin system toxin PepG1 -
- 2827740..2827924 - 185 - - Antitoxin
PML73_RS13970 2827926..2828066 + 141 WP_073340360.1 putative holin-like toxin Toxin
PML73_RS13975 2828297..2828440 + 144 WP_002381035.1 putative holin-like toxin -
PML73_RS13980 2828635..2832462 - 3828 WP_010816211.1 WxL domain-containing protein -
PML73_RS13985 2832449..2832811 - 363 WP_002378868.1 LPXTG cell wall anchor domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-46)


Sequences

Toxin        


Download         Length: 47 a.a.        Molecular weight: 5218.33 Da        Isoelectric Point: 10.3265

>T269017 WP_073340360.1 NZ_CP116571:2827926-2828066 [Enterococcus faecalis]
ISLKNTNKNIVYCTTYETIQTILGFGMFTIALIALIVKLLKNDKKK

Download         Length: 141 bp

Antitoxin


Download         Length: 185 bp

>AT269017 NZ_CP116571:c2827924-2827740 [Enterococcus faecalis]
TGCTACAATAGAGACGAAAAGAGAGGTATGCTCTAACATACCTCTCTAGTGTAGAGCCGTTTAAGACGGTGACCTTTTTA
GTTACAAAAAATAACCGTACTCAGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGCGCA
ATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3N3Z2N6

Antitoxin

Download structure file

References