Detailed information of TA system TA269015

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2827658..2827924
• Replicon: chromosome
• Accession: NZ_CP116571
• Organism: Enterococcus faecalis strain K190-1

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: PML73_RS13965
• Protein ID: WP_002411240.1
• Coordinates: 2827658..2827807 (+)
• Length: 50 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2827740..2827924 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PML73_RS13945	2822779..2822994	-	216	WP_002354768.1	zinc ribbon domain-containing protein	-
PML73_RS13950	2823133..2824125	+	993	WP_002389493.1	biotin--[acetyl-CoA-carboxylase] ligase	-
PML73_RS13955	2824389..2825027	-	639	WP_271865427.1	lytic polysaccharide monooxygenase	-
PML73_RS13960	2825713..2827329	+	1617	WP_002389442.1	phosphatase PAP2/LCP family protein	-
PML73_RS13965	2827658..2827807	+	150	WP_002411240.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	2827740..2827924	-	185	-	-	Antitoxin
PML73_RS13970	2827926..2828066	+	141	WP_073340360.1	putative holin-like toxin	-
PML73_RS13975	2828297..2828440	+	144	WP_002381035.1	putative holin-like toxin	-
PML73_RS13980	2828635..2832462	-	3828	WP_010816211.1	WxL domain-containing protein	-
PML73_RS13985	2832449..2832811	-	363	WP_002378868.1	LPXTG cell wall anchor domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (16-49)

Sequences

Toxin

Protein

• Length: 50 a.a.
• Molecular weight: 5738.05 Da
• Isoelectric Point: 11.3858

>T269015 WP_002411240.1 NZ_CP116571:2827658-2827807 [Enterococcus faecalis]
MRMHVFPKFRERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDKKK

Nucleotide

• Length: 150 bp

Antitoxin

Nucleotide

• Length: 185 bp

>AT269015 NZ_CP116571:c2827924-2827740 [Enterococcus faecalis]
TGCTACAATAGAGACGAAAAGAGAGGTATGCTCTAACATACCTCTCTAGTGTAGAGCCGTTTAAGACGGTGACCTTTTTA
GTTACAAAAAATAACCGTACTCAGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGCGCA
ATCAAAGCAATGGTAAACATACCAA

Structures

Antitoxin