Detailed information of TA system TA269012

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2754799..2755061
• Replicon: chromosome
• Accession: NZ_CP116571
• Organism: Enterococcus faecalis strain K190-1

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: PML73_RS13635
• Protein ID: WP_002367458.1
• Coordinates: 2754918..2755061 (-)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2754799..2754985 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PML73_RS13620	2750256..2753000	+	2745	WP_002411259.1	glycosyl hydrolase family 65 protein	-
PML73_RS13625	2753015..2753665	+	651	WP_002389419.1	beta-phosphoglucomutase	-
PML73_RS13630	2754085..2754678	+	594	WP_002389391.1	PBECR4 domain-containing protein	-
-	2754799..2754985	+	187	-	-	Antitoxin
PML73_RS13635	2754918..2755061	-	144	WP_002367458.1	type I toxin-antitoxin system toxin PepG1	Toxin
PML73_RS13640	2755293..2756264	-	972	WP_002381060.1	ribose-phosphate diphosphokinase	-
PML73_RS13645	2756439..2756876	-	438	WP_002389480.1	peptide-methionine (R)-S-oxide reductase MsrB	-
PML73_RS13650	2757009..2757563	-	555	WP_002354869.1	Maf family protein	-
PML73_RS13655	2757588..2759720	-	2133	WP_002389406.1	DNA mismatch repair endonuclease MutL	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5311.50 Da
• Isoelectric Point: 10.8331

>T269012 WP_002367458.1 NZ_CP116571:c2755061-2754918 [Enterococcus faecalis]
MSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDKKK

Nucleotide

• Length: 144 bp

Antitoxin

Nucleotide

• Length: 187 bp

>AT269012 NZ_CP116571:2754799-2754985 [Enterococcus faecalis]
TGTGCTAGAATGTAGATGAAAAGAGAGATATGCGTCAACATACCTCTCTAGTGTAGAGCCGTTTGAGACGGTGACCGATT
GTATTATTTAAAAATAACCGTACTGGTCAAAGTAGATGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGTG
CAATCAAAGCAATGGTAAACATACCAA

Structures

Antitoxin