Detailed information of TA system TA269004

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2683259..2683516
• Replicon: chromosome
• Accession: NZ_CP116571
• Organism: Enterococcus faecalis strain K190-1

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: PML73_RS13300
• Protein ID: WP_021164441.1
• Coordinates: 2683415..2683516 (-)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2683259..2683466 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PML73_RS13275	2678943..2679896	-	954	WP_002370087.1	siderophore ABC transporter substrate-binding protein	-
PML73_RS13280	2679935..2680690	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
PML73_RS13285	2680687..2681652	-	966	WP_002371665.1	iron chelate uptake ABC transporter family permease subunit	-
PML73_RS13290	2681649..2682596	-	948	WP_002354960.1	iron chelate uptake ABC transporter family permease subunit	-
PML73_RS13295	2682781..2683233	+	453	WP_002389410.1	YueI family protein	-
-	2683259..2683466	+	208	-	-	Antitoxin
PML73_RS13300	2683415..2683516	-	102	WP_021164441.1	putative holin-like toxin	Toxin
PML73_RS13305	2683848..2683949	-	102	WP_075551663.1	putative holin-like toxin	-
PML73_RS13310	2684139..2686409	-	2271	WP_002389492.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
PML73_RS13315	2686580..2687080	+	501	WP_002372831.1	cysteine hydrolase family protein	-
PML73_RS13320	2687479..2688375	+	897	WP_002389477.1	YitT family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3598.36 Da
• Isoelectric Point: 6.0656

>T269004 WP_021164441.1 NZ_CP116571:c2683516-2683415 [Enterococcus faecalis]
MSIEAALELMISFAAFVALLIFGILEATKNNKK

Nucleotide

• Length: 102 bp

Antitoxin

Nucleotide

• Length: 208 bp

>AT269004 NZ_CP116571:2683259-2683466 [Enterococcus faecalis]
TTCCATTTATAATAGAATTATGCTATTATAAAGATGAAAAAGAGAGGTATGCGGGTACATACCTCTCCTTTTATACCAAC
ACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTTTGAATCTTAACCGTTCGGCCTACGAAGCTTGTGAACGGTTAT
TTTTTATTGTTTTTCGTTGCTTCAAGGATACCGAAAATCAGTAGTGCA

Structures

Antitoxin