Detailed information of TA system TA268983

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2486525..2486785
• Replicon: chromosome
• Accession: NZ_CP116569
• Organism: Enterococcus faecalis strain K198-1

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: PML91_RS11840
• Protein ID: WP_075551663.1
• Coordinates: 2486684..2486785 (-)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2486525..2486735 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PML91_RS11815	2482209..2483162	-	954	WP_231432877.1	siderophore ABC transporter substrate-binding protein	-
PML91_RS11820	2483201..2483956	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
PML91_RS11825	2483953..2484918	-	966	WP_002354961.1	iron chelate uptake ABC transporter family permease subunit	-
PML91_RS11830	2484915..2485862	-	948	WP_002354960.1	iron chelate uptake ABC transporter family permease subunit	-
PML91_RS11835	2486047..2486499	+	453	WP_010710887.1	YueI family protein	-
-	2486525..2486735	+	211	-	-	Antitoxin
PML91_RS11840	2486684..2486785	-	102	WP_075551663.1	putative holin-like toxin	Toxin
PML91_RS11845	2486974..2489244	-	2271	WP_002354955.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
PML91_RS11850	2489415..2489915	+	501	WP_016627679.1	cysteine hydrolase family protein	-
PML91_RS11855	2490261..2491157	+	897	WP_002365354.1	YitT family protein	-
PML91_RS11860	2491208..2491606	-	399	WP_002354951.1	glyoxalase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3599.34 Da
• Isoelectric Point: 4.5869

>T268983 WP_075551663.1 NZ_CP116569:c2486785-2486684 [Enterococcus faecalis]
MSIEAALELMISFAAFVALLIFGILEATKNDKK

Nucleotide

• Length: 102 bp

Antitoxin

Nucleotide

• Length: 211 bp

>AT268983 NZ_CP116569:2486525-2486735 [Enterococcus faecalis]
TTCCATTTATAATAGAATTATGCTATTATGAAAATGAAAAAGAGAGGTATGCGGGTACATACCTCTCTTTTATACCAGCG
CCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTTTTATTACTGTTTAACCGTTCGGCCTGTCAAGCTTATGAACGGT
TATTTTTTATCGTTTTTCGTTGCTTCAAGGATACCGAAAATCAGTAGTGCA

Structures

Antitoxin