Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 471456..471688 Replicon chromosome
Accession NZ_CP116569
Organism Enterococcus faecalis strain K198-1

Toxin (Protein)


Gene name txpA Uniprot ID C7CXQ5
Locus tag PML91_RS02315 Protein ID WP_002355568.1
Coordinates 471456..471572 (+) Length 39 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 471483..471688 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PML91_RS02305 466894..469152 + 2259 WP_002364805.1 DNA helicase PcrA -
PML91_RS02310 469278..471308 + 2031 WP_010710796.1 NAD-dependent DNA ligase LigA -
PML91_RS02315 471456..471572 + 117 WP_002355568.1 putative holin-like toxin Toxin
- 471483..471688 - 206 - - Antitoxin
PML91_RS02320 471890..472195 + 306 WP_002355569.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC -
PML91_RS02325 472195..473664 + 1470 WP_002361259.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA -
PML91_RS02330 473664..475094 + 1431 WP_002358703.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB -
PML91_RS02335 475113..476201 + 1089 WP_002355572.1 diacylglycerol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(3-35)


Sequences

Toxin        


Download         Length: 39 a.a.        Molecular weight: 4065.93 Da        Isoelectric Point: 5.9482

>T268981 WP_002355568.1 NZ_CP116569:471456-471572 [Enterococcus faecalis]
MFLSVEAALGLMIGFATLVVTIIFGILALVLDNKNNRS

Download         Length: 117 bp

Antitoxin


Download         Length: 206 bp

>AT268981 NZ_CP116569:c471688-471483 [Enterococcus faecalis]
AAAAGAGAGATATGCAGGAACATACCTCTCTAGTAGCCACTACTAGTTATAAGAACTAGCGGCTTACTGAGTTATTGGTT
TTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTTGTTGTCTAAGACAAGCGCTAAGATAC
CGAAGATAATGGTCACAACAAGTGTTGCAAAACCAATCATCAGTCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B4XLM6

Antitoxin

Download structure file

References