Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2680528..2680845 Replicon chromosome
Accession NZ_CP116566
Organism Enterococcus faecalis strain K191-1

Toxin (Protein)


Gene name txpA Uniprot ID S4BWW4
Locus tag PML79_RS12970 Protein ID WP_002404776.1
Coordinates 2680528..2680650 (+) Length 41 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2680583..2680845 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PML79_RS12950 (2676174) 2676174..2676560 - 387 WP_244323692.1 RloB domain-containing protein -
PML79_RS12955 (2676512) 2676512..2676790 - 279 WP_253544428.1 RloB family protein -
PML79_RS12960 (2676799) 2676799..2678094 - 1296 WP_010824051.1 ATP-binding protein -
PML79_RS12965 (2678556) 2678556..2680172 + 1617 WP_002372620.1 phosphatase PAP2/LCP family protein -
PML79_RS12970 (2680528) 2680528..2680650 + 123 WP_002404776.1 putative holin-like toxin Toxin
- (2680583) 2680583..2680845 - 263 NuclAT_7 - Antitoxin
- (2680716) 2680716..2680847 - 132 NuclAT_10 - -
PML79_RS12975 (2680848) 2680848..2684750 - 3903 WP_113821080.1 WxL domain-containing protein -
PML79_RS12980 (2684737) 2684737..2685099 - 363 WP_010776206.1 LPXTG cell wall anchor domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(7-40)


Sequences

Toxin        


Download         Length: 41 a.a.        Molecular weight: 4396.44 Da        Isoelectric Point: 10.2826

>T268975 WP_002404776.1 NZ_CP116566:2680528-2680650 [Enterococcus faecalis]
MKGVGLLSAYETIQTILGFGMFTIALIALIVKLLKEDKKK

Download         Length: 123 bp

Antitoxin


Download         Length: 263 bp

>AT268975 NZ_CP116566:c2680845-2680583 [Enterococcus faecalis]
ATAAAAATGCCCGAGCCTTGAAATAGGAGGCTCGGGCATCTTTTATTGATGGTCTTTTTAGGGGCGTTGTGCTATAATGG
TAATGAGAAGAGAGATATGCTGTAACATACCTCTCTAGTGTAGAGCCGTTACTAACGGTGACAAAATTTTAAAGATTTTG
AAATGACCGTCTAACTAGGCAAAGTTAAACAGCGGTCATTTCTTTTTGTCTTCTTTAAGCAATTTCACAATCAGTGCAAT
CAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S4BWW4

Antitoxin

Download structure file

References