Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2604535..2605042 Replicon chromosome
Accession NZ_CP116566
Organism Enterococcus faecalis strain K191-1

Toxin (Protein)


Gene name txpA Uniprot ID S4BYM2
Locus tag PML79_RS12625 Protein ID WP_002392696.1
Coordinates 2604535..2604678 (-) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2604855..2605042 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PML79_RS12610 (2599830) 2599830..2602574 + 2745 WP_104876100.1 glycosyl hydrolase family 65 protein -
PML79_RS12615 (2602589) 2602589..2603239 + 651 WP_085443093.1 beta-phosphoglucomutase -
PML79_RS12620 (2603701) 2603701..2604294 + 594 WP_010706987.1 PBECR4 domain-containing protein -
- (2604417) 2604417..2604602 + 186 NuclAT_6 - -
PML79_RS12625 (2604535) 2604535..2604678 - 144 WP_002392696.1 type I toxin-antitoxin system toxin PepG1 Toxin
- (2604855) 2604855..2605042 + 188 NuclAT_5 - Antitoxin
PML79_RS12630 (2604975) 2604975..2605118 - 144 WP_002392696.1 type I toxin-antitoxin system toxin PepG1 -
PML79_RS12635 (2605351) 2605351..2606322 - 972 WP_002381060.1 ribose-phosphate diphosphokinase -
PML79_RS12640 (2606497) 2606497..2606934 - 438 WP_002354871.1 peptide-methionine (R)-S-oxide reductase MsrB -
PML79_RS12645 (2607067) 2607067..2607621 - 555 WP_002354869.1 Maf family protein -
PML79_RS12650 (2607646) 2607646..2609778 - 2133 WP_010713705.1 DNA mismatch repair endonuclease MutL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5297.43 Da        Isoelectric Point: 10.6867

>T268970 WP_002392696.1 NZ_CP116566:c2604678-2604535 [Enterococcus faecalis]
MSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Download         Length: 144 bp

Antitoxin


Download         Length: 188 bp

>AT268970 NZ_CP116566:2604855-2605042 [Enterococcus faecalis]
TGTGCTATAATGAAAACGAAAAGAGAGAGATGCGTCAACATACCTCTCTGATGTAGAGCCGTTTAAGACGGTGACCATGT
TAATTATTTAAAAATAACCGTGCTTGGTCAAAGTTGACGGTTATTTTTTATTGTCATTTTTAAGCAATTTAACAATCAGC
GCAATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S4BYM2

Antitoxin

Download structure file

References