Detailed information of TA system TA268965

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2534742..2534998
• Replicon: chromosome
• Accession: NZ_CP116566
• Organism: Enterococcus faecalis strain K191-1

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: PML79_RS12300
• Protein ID: WP_224800345.1
• Coordinates: 2534897..2534998 (-)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2534742..2534943 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PML79_RS12270 (2529961)	2529961..2530914	-	954	WP_002359060.1	siderophore ABC transporter substrate-binding protein	-
PML79_RS12275 (2530953)	2530953..2531708	-	756	WP_010776168.1	ATP-binding cassette domain-containing protein	-
PML79_RS12280 (2531705)	2531705..2532670	-	966	WP_085443086.1	iron chelate uptake ABC transporter family permease subunit	-
PML79_RS12285 (2532667)	2532667..2533614	-	948	WP_085443087.1	iron chelate uptake ABC transporter family permease subunit	-
PML79_RS12290 (2533799)	2533799..2534251	+	453	WP_010707017.1	YueI family protein	-
- (2534307)	2534307..2534512	+	206	NuclAT_4	-	-
- (2534344)	2534344..2534529	+	186	NuclAT_9	-	-
PML79_RS12295 (2534466)	2534466..2534567	-	102	WP_162780856.1	putative holin-like toxin	-
- (2534742)	2534742..2534943	+	202	NuclAT_3	-	Antitoxin
- (2534776)	2534776..2534960	+	185	NuclAT_8	-	-
PML79_RS12300 (2534897)	2534897..2534998	-	102	WP_224800345.1	putative holin-like toxin	Toxin
PML79_RS12305 (2535187)	2535187..2537457	-	2271	WP_085443088.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
PML79_RS12310 (2537628)	2537628..2538134	+	507	WP_010824004.1	cysteine hydrolase family protein	-
PML79_RS12315 (2538324)	2538324..2539220	+	897	WP_002354953.1	YitT family protein	-
PML79_RS12320 (2539271)	2539271..2539669	-	399	WP_002354951.1	glyoxalase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3594.37 Da
• Isoelectric Point: 6.0656

>T268965 WP_224800345.1 NZ_CP116566:c2534998-2534897 [Enterococcus faecalis]
MSIEAALELMISFATLVALLIFGILEATKNNKK

Nucleotide

• Length: 102 bp

Antitoxin

Nucleotide

• Length: 202 bp

>AT268965 NZ_CP116566:2534742-2534943 [Enterococcus faecalis]
TTCCATTTTAAATAGAATTATGCTATTATGAAAATGAAAAGAGAGATATGCTACTACATACCTCTCCTTTTATACCAACA
CCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTTTGAATCTTAACCGTTCGGCCTACGAAGCTTGTGAACGGTTATT
TTTTATTGTTTTTCGTTGCTTCAAGGATACCGAAAATCAGTA

Structures

Antitoxin