Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 482413..482645 Replicon chromosome
Accession NZ_CP116566
Organism Enterococcus faecalis strain K191-1

Toxin (Protein)


Gene name txpA Uniprot ID C7CXQ5
Locus tag PML79_RS02405 Protein ID WP_002355568.1
Coordinates 482413..482529 (+) Length 39 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 482440..482645 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PML79_RS02395 (477851) 477851..480109 + 2259 WP_002363179.1 DNA helicase PcrA -
PML79_RS02400 (480235) 480235..482265 + 2031 WP_010828568.1 NAD-dependent DNA ligase LigA -
PML79_RS02405 (482413) 482413..482529 + 117 WP_002355568.1 putative holin-like toxin Toxin
- (482440) 482440..482645 - 206 NuclAT_2 - Antitoxin
PML79_RS02410 (482847) 482847..483152 + 306 WP_002355569.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC -
PML79_RS02415 (483152) 483152..484621 + 1470 WP_002368026.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA -
PML79_RS02420 (484621) 484621..486051 + 1431 WP_002358703.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB -
PML79_RS02425 (486070) 486070..487158 + 1089 WP_002383001.1 diacylglycerol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(3-35)


Sequences

Toxin        


Download         Length: 39 a.a.        Molecular weight: 4065.93 Da        Isoelectric Point: 5.9482

>T268959 WP_002355568.1 NZ_CP116566:482413-482529 [Enterococcus faecalis]
MFLSVEAALGLMIGFATLVVTIIFGILALVLDNKNNRS

Download         Length: 117 bp

Antitoxin


Download         Length: 206 bp

>AT268959 NZ_CP116566:c482645-482440 [Enterococcus faecalis]
AAAAGAGAGATATGCAGGAACATACCTCTCTAGTAGCCACTACTAGTTATAAGAACTAGCGGCTTACTGAGTTATTGGTT
TTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTTGTTGTCTAAGACAAGCGCTAAGATGC
CGAAGATAATGGTCACAACAAGTGTTGCAAAACCAATCATCAGTCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B4XLM6

Antitoxin

Download structure file

References