268953

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2730688..2731005 Replicon chromosome
Accession NZ_CP116564
Organism Enterococcus faecalis strain K188-1

Toxin (Protein)


Gene name txpA Uniprot ID S4BWW4
Locus tag PML72_RS13365 Protein ID WP_002404776.1
Coordinates 2730688..2730810 (+) Length 41 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2730743..2731005 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PML72_RS13345 (2726334) 2726334..2726720 - 387 WP_244323692.1 RloB domain-containing protein -
PML72_RS13350 (2726672) 2726672..2726950 - 279 WP_253544428.1 RloB family protein -
PML72_RS13355 (2726959) 2726959..2728254 - 1296 WP_010824051.1 ATP-binding protein -
PML72_RS13360 (2728716) 2728716..2730332 + 1617 WP_002372620.1 phosphatase PAP2/LCP family protein -
PML72_RS13365 (2730688) 2730688..2730810 + 123 WP_002404776.1 putative holin-like toxin Toxin
- (2730743) 2730743..2731005 - 263 NuclAT_7 - Antitoxin
- (2730876) 2730876..2731007 - 132 NuclAT_10 - -
PML72_RS13370 (2731008) 2731008..2734910 - 3903 WP_113821080.1 WxL domain-containing protein -
PML72_RS13375 (2734897) 2734897..2735259 - 363 WP_010776206.1 LPXTG cell wall anchor domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(7-40)


Sequences

Toxin        


Download         Length: 41 a.a.        Molecular weight: 4396.44 Da        Isoelectric Point: 10.2826

>T268953 WP_002404776.1 NZ_CP116564:2730688-2730810 [Enterococcus faecalis]
MKGVGLLSAYETIQTILGFGMFTIALIALIVKLLKEDKKK

Download         Length: 123 bp

Antitoxin


Download         Length: 263 bp

>AT268953 NZ_CP116564:c2731005-2730743 [Enterococcus faecalis]
ATAAAAATGCCCGAGCCTTGAAATAGGAGGCTCGGGCATCTTTTATTGATGGTCTTTTTAGGGGCGTTGTGCTATAATGG
TAATGAGAAGAGAGATATGCTGTAACATACCTCTCTAGTGTAGAGCCGTTACTAACGGTGACAAAATTTTAAAGATTTTG
AAATGACCGTCTAACTAGGCAAAGTTAAACAGCGGTCATTTCTTTTTGTCTTCTTTAAGCAATTTCACAATCAGTGCAAT
CAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S4BWW4

Antitoxin

Download structure file

References