Detailed information of TA system TA268941

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2584626..2585103
• Replicon: chromosome
• Accession: NZ_CP116564
• Organism: Enterococcus faecalis strain K188-1

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: PML72_RS12690
• Protein ID: WP_162780856.1
• Coordinates: 2584626..2584727 (-)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2584902..2585103 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PML72_RS12665 (2580121)	2580121..2581074	-	954	WP_002359060.1	siderophore ABC transporter substrate-binding protein	-
PML72_RS12670 (2581113)	2581113..2581868	-	756	WP_010776168.1	ATP-binding cassette domain-containing protein	-
PML72_RS12675 (2581865)	2581865..2582830	-	966	WP_085443086.1	iron chelate uptake ABC transporter family permease subunit	-
PML72_RS12680 (2582827)	2582827..2583774	-	948	WP_085443087.1	iron chelate uptake ABC transporter family permease subunit	-
PML72_RS12685 (2583959)	2583959..2584411	+	453	WP_010707017.1	YueI family protein	-
- (2584467)	2584467..2584672	+	206	NuclAT_4	-	-
- (2584504)	2584504..2584689	+	186	NuclAT_9	-	-
PML72_RS12690 (2584626)	2584626..2584727	-	102	WP_162780856.1	putative holin-like toxin	Toxin
- (2584902)	2584902..2585103	+	202	NuclAT_3	-	Antitoxin
- (2584936)	2584936..2585120	+	185	NuclAT_8	-	-
PML72_RS12695 (2585057)	2585057..2585158	-	102	WP_224800345.1	putative holin-like toxin	-
PML72_RS12700 (2585347)	2585347..2587617	-	2271	WP_085443088.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
PML72_RS12705 (2587788)	2587788..2588294	+	507	WP_010824004.1	cysteine hydrolase family protein	-
PML72_RS12710 (2588484)	2588484..2589380	+	897	WP_002354953.1	YitT family protein	-
PML72_RS12715 (2589431)	2589431..2589829	-	399	WP_002354951.1	glyoxalase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3624.40 Da
• Isoelectric Point: 6.0656

>T268941 WP_162780856.1 NZ_CP116564:c2584727-2584626 [Enterococcus faecalis]
MSIEATLELMISFATLVALLIFGILEATKNNKK

Nucleotide

• Length: 102 bp

Antitoxin

Nucleotide

• Length: 202 bp

>AT268941 NZ_CP116564:2584902-2585103 [Enterococcus faecalis]
TTCCATTTTAAATAGAATTATGCTATTATGAAAATGAAAAGAGAGATATGCTACTACATACCTCTCCTTTTATACCAACA
CCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTTTGAATCTTAACCGTTCGGCCTACGAAGCTTGTGAACGGTTATT
TTTTATTGTTTTTCGTTGCTTCAAGGATACCGAAAATCAGTA

Structures

Antitoxin