Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2729541..2729858 Replicon chromosome
Accession NZ_CP116561
Organism Enterococcus faecalis strain K72-1

Toxin (Protein)


Gene name txpA Uniprot ID S4BWW4
Locus tag PML97_RS13350 Protein ID WP_002404776.1
Coordinates 2729541..2729663 (+) Length 41 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2729596..2729858 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PML97_RS13330 (2725187) 2725187..2725573 - 387 WP_244323692.1 RloB domain-containing protein -
PML97_RS13335 (2725525) 2725525..2725803 - 279 WP_253544428.1 RloB family protein -
PML97_RS13340 (2725812) 2725812..2727107 - 1296 WP_010824051.1 ATP-binding protein -
PML97_RS13345 (2727569) 2727569..2729185 + 1617 WP_002372620.1 phosphatase PAP2/LCP family protein -
PML97_RS13350 (2729541) 2729541..2729663 + 123 WP_002404776.1 putative holin-like toxin Toxin
- (2729596) 2729596..2729858 - 263 NuclAT_7 - Antitoxin
- (2729729) 2729729..2729860 - 132 NuclAT_10 - -
PML97_RS13355 (2729861) 2729861..2733763 - 3903 WP_113821080.1 WxL domain-containing protein -
PML97_RS13360 (2733750) 2733750..2734112 - 363 WP_010776206.1 LPXTG cell wall anchor domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(7-40)


Sequences

Toxin        


Download         Length: 41 a.a.        Molecular weight: 4396.44 Da        Isoelectric Point: 10.2826

>T268930 WP_002404776.1 NZ_CP116561:2729541-2729663 [Enterococcus faecalis]
MKGVGLLSAYETIQTILGFGMFTIALIALIVKLLKEDKKK

Download         Length: 123 bp

Antitoxin


Download         Length: 263 bp

>AT268930 NZ_CP116561:c2729858-2729596 [Enterococcus faecalis]
ATAAAAATGCCCGAGCCTTGAAATAGGAGGCTCGGGCATCTTTTATTGATGGTCTTTTTAGGGGCGTTGTGCTATAATGG
TAATGAGAAGAGAGATATGCTGTAACATACCTCTCTAGTGTAGAGCCGTTACTAACGGTGACAAAATTTTAAAGATTTTG
AAATGACCGTCTAACTAGGCAAAGTTAAACAGCGGTCATTTCTTTTTGTCTTCTTTAAGCAATTTCACAATCAGTGCAAT
CAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S4BWW4

Antitoxin

Download structure file

References