Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2653868..2654131 Replicon chromosome
Accession NZ_CP116561
Organism Enterococcus faecalis strain K72-1

Toxin (Protein)


Gene name txpA Uniprot ID S4BYM2
Locus tag PML97_RS13010 Protein ID WP_002392696.1
Coordinates 2653988..2654131 (-) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2653868..2654055 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PML97_RS12995 (2651602) 2651602..2652252 + 651 WP_085443093.1 beta-phosphoglucomutase -
PML97_RS13000 (2652714) 2652714..2653307 + 594 WP_010706987.1 PBECR4 domain-containing protein -
- (2653430) 2653430..2653615 + 186 NuclAT_6 - -
PML97_RS13005 (2653548) 2653548..2653691 - 144 WP_002392696.1 type I toxin-antitoxin system toxin PepG1 -
- (2653868) 2653868..2654055 + 188 NuclAT_5 - Antitoxin
PML97_RS13010 (2653988) 2653988..2654131 - 144 WP_002392696.1 type I toxin-antitoxin system toxin PepG1 Toxin
PML97_RS13015 (2654364) 2654364..2655335 - 972 WP_002381060.1 ribose-phosphate diphosphokinase -
PML97_RS13020 (2655510) 2655510..2655947 - 438 WP_002354871.1 peptide-methionine (R)-S-oxide reductase MsrB -
PML97_RS13025 (2656080) 2656080..2656634 - 555 WP_002354869.1 Maf family protein -
PML97_RS13030 (2656659) 2656659..2658791 - 2133 WP_010713705.1 DNA mismatch repair endonuclease MutL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5297.43 Da        Isoelectric Point: 10.6867

>T268927 WP_002392696.1 NZ_CP116561:c2654131-2653988 [Enterococcus faecalis]
MSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Download         Length: 144 bp

Antitoxin


Download         Length: 188 bp

>AT268927 NZ_CP116561:2653868-2654055 [Enterococcus faecalis]
TGTGCTATAATGAAAACGAAAAGAGAGAGATGCGTCAACATACCTCTCTGATGTAGAGCCGTTTAAGACGGTGACCATGT
TAATTATTTAAAAATAACCGTGCTTGGTCAAAGTTGACGGTTATTTTTTATTGTCATTTTTAAGCAATTTAACAATCAGC
GCAATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S4BYM2

Antitoxin

Download structure file

References