Detailed information of TA system TA268918

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2583479..2583956
• Replicon: chromosome
• Accession: NZ_CP116561
• Organism: Enterococcus faecalis strain K72-1

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: PML97_RS12675
• Protein ID: WP_162780856.1
• Coordinates: 2583479..2583580 (-)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2583755..2583956 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PML97_RS12650 (2578974)	2578974..2579927	-	954	WP_002359060.1	siderophore ABC transporter substrate-binding protein	-
PML97_RS12655 (2579966)	2579966..2580721	-	756	WP_010776168.1	ATP-binding cassette domain-containing protein	-
PML97_RS12660 (2580718)	2580718..2581683	-	966	WP_085443086.1	iron chelate uptake ABC transporter family permease subunit	-
PML97_RS12665 (2581680)	2581680..2582627	-	948	WP_085443087.1	iron chelate uptake ABC transporter family permease subunit	-
PML97_RS12670 (2582812)	2582812..2583264	+	453	WP_010707017.1	YueI family protein	-
- (2583320)	2583320..2583525	+	206	NuclAT_4	-	-
- (2583357)	2583357..2583542	+	186	NuclAT_9	-	-
PML97_RS12675 (2583479)	2583479..2583580	-	102	WP_162780856.1	putative holin-like toxin	Toxin
- (2583755)	2583755..2583956	+	202	NuclAT_3	-	Antitoxin
- (2583789)	2583789..2583973	+	185	NuclAT_8	-	-
PML97_RS12680 (2583910)	2583910..2584011	-	102	WP_224800345.1	putative holin-like toxin	-
PML97_RS12685 (2584200)	2584200..2586470	-	2271	WP_085443088.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
PML97_RS12690 (2586641)	2586641..2587147	+	507	WP_010824004.1	cysteine hydrolase family protein	-
PML97_RS12695 (2587337)	2587337..2588233	+	897	WP_002354953.1	YitT family protein	-
PML97_RS12700 (2588284)	2588284..2588682	-	399	WP_002354951.1	glyoxalase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3624.40 Da
• Isoelectric Point: 6.0656

>T268918 WP_162780856.1 NZ_CP116561:c2583580-2583479 [Enterococcus faecalis]
MSIEATLELMISFATLVALLIFGILEATKNNKK

Nucleotide

• Length: 102 bp

Antitoxin

Nucleotide

• Length: 202 bp

>AT268918 NZ_CP116561:2583755-2583956 [Enterococcus faecalis]
TTCCATTTTAAATAGAATTATGCTATTATGAAAATGAAAAGAGAGATATGCTACTACATACCTCTCCTTTTATACCAACA
CCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTTTGAATCTTAACCGTTCGGCCTACGAAGCTTGTGAACGGTTATT
TTTTATTGTTTTTCGTTGCTTCAAGGATACCGAAAATCAGTA

Structures

Antitoxin