Detailed information of TA system TA268908

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2658020..2658354
• Replicon: chromosome
• Accession: NZ_CP116559
• Organism: Enterococcus faecalis strain K137-1a

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: PML94_RS12595
• Protein ID: WP_002415596.1
• Coordinates: 2658020..2658163 (+)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2658096..2658354 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PML94_RS12575 (2653088)	2653088..2653303	-	216	WP_002354768.1	zinc ribbon domain-containing protein	-
PML94_RS12580 (2653442)	2653442..2654434	+	993	WP_002358973.1	biotin--[acetyl-CoA-carboxylase] ligase	-
PML94_RS12585 (2654738)	2654738..2655376	-	639	WP_002375448.1	lytic polysaccharide monooxygenase	-
PML94_RS12590 (2656063)	2656063..2657679	+	1617	WP_002372620.1	phosphatase PAP2/LCP family protein	-
PML94_RS12595 (2658020)	2658020..2658163	+	144	WP_002415596.1	type I toxin-antitoxin system toxin PepG1	Toxin
- (2658096)	2658096..2658354	-	259	NuclAT_3	-	Antitoxin
- (2658305)	2658305..2658355	+	51	NuclAT_13	-	-
PML94_RS12600 (2658356)	2658356..2662123	-	3768	WP_104807327.1	WxL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5314.46 Da
• Isoelectric Point: 10.6323

>T268908 WP_002415596.1 NZ_CP116559:2658020-2658163 [Enterococcus faecalis]
MNVSAKIYERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDKKK

Nucleotide

• Length: 144 bp

Antitoxin

Nucleotide

• Length: 259 bp

>AT268908 NZ_CP116559:c2658354-2658096 [Enterococcus faecalis]
ATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTTATTGATGGTCTTTTTAGGGTTGTTGTGCTATAA
TGATAAAGAAAAGAGAGATATGCTTCCAACATATCTCTCTGATGTAGAGCCGTTTAAGACGGTGACCAATTTTATTACTT
AAAAATAACCGTACTTGGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGCGCAATCAAA
GCAATGGTAAACATACCAA

Structures

Antitoxin