Detailed information of TA system TA268905

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2579575..2579846
• Replicon: chromosome
• Accession: NZ_CP116559
• Organism: Enterococcus faecalis strain K137-1a

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: PML94_RS12245
• Protein ID: WP_002375510.1
• Coordinates: 2579694..2579846 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2579575..2579761 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PML94_RS12230 (2575542)	2575542..2578286	+	2745	WP_104807179.1	glycosyl hydrolase family 65 protein	-
PML94_RS12235 (2578301)	2578301..2578951	+	651	WP_002375514.1	beta-phosphoglucomutase	-
- (2579020)	2579020..2579152	+	133	NuclAT_12	-	-
- (2579199)	2579199..2579386	+	188	NuclAT_4	-	-
PML94_RS12240 (2579319)	2579319..2579423	-	105	WP_023894767.1	putative holin-like toxin	-
- (2579575)	2579575..2579720	+	146	NuclAT_11	-	-
- (2579575)	2579575..2579761	+	187	NuclAT_5	-	Antitoxin
PML94_RS12245 (2579694)	2579694..2579846	-	153	WP_002375510.1	type I toxin-antitoxin system toxin PepG1	Toxin
PML94_RS12250 (2580071)	2580071..2581042	-	972	WP_002381060.1	ribose-phosphate diphosphokinase	-
PML94_RS12255 (2581217)	2581217..2581654	-	438	WP_002354871.1	peptide-methionine (R)-S-oxide reductase MsrB	-
PML94_RS12260 (2581787)	2581787..2582341	-	555	WP_002354869.1	Maf family protein	-
PML94_RS12265 (2582366)	2582366..2584498	-	2133	WP_002375508.1	DNA mismatch repair endonuclease MutL	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (17-50)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5637.90 Da
• Isoelectric Point: 11.0942

>T268905 WP_002375510.1 NZ_CP116559:c2579846-2579694 [Enterococcus faecalis]
VVRMSALPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDKKK

Nucleotide

• Length: 153 bp

Antitoxin

Nucleotide

• Length: 187 bp

>AT268905 NZ_CP116559:2579575-2579761 [Enterococcus faecalis]
TGTGCTATAATGAAAATGAAAAGAGAGATATGAGTCAACATACCTCTCTAGTGTAGAGCCGTTTGAGACGGTGACCGATT
GTATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTTTTGTCATTTTTAAGCAATTTCACAATCAGTG
CAATCAAAGCAATGGTAAACATACCAA

Structures

Antitoxin