Detailed information of TA system TA268899

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2500678..2500902
• Replicon: chromosome
• Accession: NZ_CP116559
• Organism: Enterococcus faecalis strain K137-1a

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: PML94_RS11870
• Protein ID: WP_162780856.1
• Coordinates: 2500801..2500902 (-)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2500678..2500864 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PML94_RS11845 (2496296)	2496296..2497249	-	954	WP_002375576.1	siderophore ABC transporter substrate-binding protein	-
PML94_RS11850 (2497288)	2497288..2498043	-	756	WP_002375575.1	ATP-binding cassette domain-containing protein	-
PML94_RS11855 (2498040)	2498040..2499005	-	966	WP_002371665.1	iron chelate uptake ABC transporter family permease subunit	-
PML94_RS11860 (2499002)	2499002..2499949	-	948	WP_002375573.1	iron chelate uptake ABC transporter family permease subunit	-
PML94_RS11865 (2500133)	2500133..2500585	+	453	WP_002375572.1	YueI family protein	-
- (2500641)	2500641..2500847	+	207	NuclAT_7	-	-
- (2500678)	2500678..2500864	+	187	NuclAT_9	-	Antitoxin
PML94_RS11870 (2500801)	2500801..2500902	-	102	WP_162780856.1	putative holin-like toxin	Toxin
PML94_RS11875 (2501094)	2501094..2503364	-	2271	WP_002368430.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
PML94_RS11880 (2503535)	2503535..2504035	+	501	WP_002395960.1	cysteine hydrolase family protein	-
PML94_RS11885 (2504834)	2504834..2505730	+	897	WP_002368434.1	YitT family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3624.40 Da
• Isoelectric Point: 6.0656

>T268899 WP_162780856.1 NZ_CP116559:c2500902-2500801 [Enterococcus faecalis]
MSIEATLELMISFATLVALLIFGILEATKNNKK

Nucleotide

• Length: 102 bp

Antitoxin

Nucleotide

• Length: 187 bp

>AT268899 NZ_CP116559:2500678-2500864 [Enterococcus faecalis]
AAAAGAGAGGTATGCGGGTACATACCTCTCCTTTATACCAGCGCCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTT
TTTATTACTGTTTAACCGTTCGGCCTGTCAAGCTTATGAACGGTTATTTTTTATTGTTTTTCGTTGCTTCAAGGATACCG
AAAATCAGTAACGCAACAAGGGTTGCA

Structures

Antitoxin