Detailed information of TA system TA268876

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2662332..2662666
• Replicon: chromosome
• Accession: NZ_CP116555
• Organism: Enterococcus faecalis strain K70-12a

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: PML75_RS12600
• Protein ID: WP_002415596.1
• Coordinates: 2662332..2662475 (+)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2662408..2662666 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PML75_RS12580 (2657400)	2657400..2657615	-	216	WP_002354768.1	zinc ribbon domain-containing protein	-
PML75_RS12585 (2657754)	2657754..2658746	+	993	WP_002358973.1	biotin--[acetyl-CoA-carboxylase] ligase	-
PML75_RS12590 (2659050)	2659050..2659688	-	639	WP_002375448.1	lytic polysaccharide monooxygenase	-
PML75_RS12595 (2660375)	2660375..2661991	+	1617	WP_002372620.1	phosphatase PAP2/LCP family protein	-
PML75_RS12600 (2662332)	2662332..2662475	+	144	WP_002415596.1	type I toxin-antitoxin system toxin PepG1	Toxin
- (2662408)	2662408..2662666	-	259	NuclAT_3	-	Antitoxin
- (2662617)	2662617..2662667	+	51	NuclAT_13	-	-
PML75_RS12605 (2662668)	2662668..2666435	-	3768	WP_104807327.1	WxL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5314.46 Da
• Isoelectric Point: 10.6323

>T268876 WP_002415596.1 NZ_CP116555:2662332-2662475 [Enterococcus faecalis]
MNVSAKIYERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDKKK

Nucleotide

• Length: 144 bp

Antitoxin

Nucleotide

• Length: 259 bp

>AT268876 NZ_CP116555:c2662666-2662408 [Enterococcus faecalis]
ATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTTATTGATGGTCTTTTTAGGGTTGTTGTGCTATAA
TGATAAAGAAAAGAGAGATATGCTTCCAACATATCTCTCTGATGTAGAGCCGTTTAAGACGGTGACCAATTTTATTACTT
AAAAATAACCGTACTTGGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGCGCAATCAAA
GCAATGGTAAACATACCAA

Structures

Antitoxin