Detailed information of TA system TA268873

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2583887..2584158
• Replicon: chromosome
• Accession: NZ_CP116555
• Organism: Enterococcus faecalis strain K70-12a

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: PML75_RS12255
• Protein ID: WP_002375510.1
• Coordinates: 2584006..2584158 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2583887..2584073 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PML75_RS12240 (2579854)	2579854..2582598	+	2745	WP_104807179.1	glycosyl hydrolase family 65 protein	-
PML75_RS12245 (2582613)	2582613..2583263	+	651	WP_002375514.1	beta-phosphoglucomutase	-
- (2583332)	2583332..2583464	+	133	NuclAT_12	-	-
- (2583511)	2583511..2583698	+	188	NuclAT_4	-	-
PML75_RS12250 (2583631)	2583631..2583735	-	105	WP_023894767.1	putative holin-like toxin	-
- (2583887)	2583887..2584032	+	146	NuclAT_11	-	-
- (2583887)	2583887..2584073	+	187	NuclAT_5	-	Antitoxin
PML75_RS12255 (2584006)	2584006..2584158	-	153	WP_002375510.1	type I toxin-antitoxin system toxin PepG1	Toxin
PML75_RS12260 (2584383)	2584383..2585354	-	972	WP_002381060.1	ribose-phosphate diphosphokinase	-
PML75_RS12265 (2585529)	2585529..2585966	-	438	WP_002354871.1	peptide-methionine (R)-S-oxide reductase MsrB	-
PML75_RS12270 (2586099)	2586099..2586653	-	555	WP_002354869.1	Maf family protein	-
PML75_RS12275 (2586678)	2586678..2588810	-	2133	WP_002375508.1	DNA mismatch repair endonuclease MutL	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (17-50)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5637.90 Da
• Isoelectric Point: 11.0942

>T268873 WP_002375510.1 NZ_CP116555:c2584158-2584006 [Enterococcus faecalis]
VVRMSALPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDKKK

Nucleotide

• Length: 153 bp

Antitoxin

Nucleotide

• Length: 187 bp

>AT268873 NZ_CP116555:2583887-2584073 [Enterococcus faecalis]
TGTGCTATAATGAAAATGAAAAGAGAGATATGAGTCAACATACCTCTCTAGTGTAGAGCCGTTTGAGACGGTGACCGATT
GTATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTTTTGTCATTTTTAAGCAATTTCACAATCAGTG
CAATCAAAGCAATGGTAAACATACCAA

Structures

Antitoxin