Detailed information of TA system TA268865

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2504953..2505214
• Replicon: chromosome
• Accession: NZ_CP116555
• Organism: Enterococcus faecalis strain K70-12a

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: PML75_RS11880
• Protein ID: WP_162780856.1
• Coordinates: 2505113..2505214 (-)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2504953..2505159 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PML75_RS11855 (2500608)	2500608..2501561	-	954	WP_002375576.1	siderophore ABC transporter substrate-binding protein	-
PML75_RS11860 (2501600)	2501600..2502355	-	756	WP_002375575.1	ATP-binding cassette domain-containing protein	-
PML75_RS11865 (2502352)	2502352..2503317	-	966	WP_002371665.1	iron chelate uptake ABC transporter family permease subunit	-
PML75_RS11870 (2503314)	2503314..2504261	-	948	WP_002375573.1	iron chelate uptake ABC transporter family permease subunit	-
PML75_RS11875 (2504445)	2504445..2504897	+	453	WP_002375572.1	YueI family protein	-
- (2504953)	2504953..2505159	+	207	NuclAT_7	-	Antitoxin
- (2504990)	2504990..2505176	+	187	NuclAT_9	-	-
PML75_RS11880 (2505113)	2505113..2505214	-	102	WP_162780856.1	putative holin-like toxin	Toxin
PML75_RS11885 (2505406)	2505406..2507676	-	2271	WP_002368430.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
PML75_RS11890 (2507847)	2507847..2508347	+	501	WP_002395960.1	cysteine hydrolase family protein	-
PML75_RS11895 (2509146)	2509146..2510042	+	897	WP_002368434.1	YitT family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3624.40 Da
• Isoelectric Point: 6.0656

>T268865 WP_162780856.1 NZ_CP116555:c2505214-2505113 [Enterococcus faecalis]
MSIEATLELMISFATLVALLIFGILEATKNNKK

Nucleotide

• Length: 102 bp

Antitoxin

Nucleotide

• Length: 207 bp

>AT268865 NZ_CP116555:2504953-2505159 [Enterococcus faecalis]
TTCCATTTATAATAGAATTGTGCTATTATGAAGATGAAAAAGAGAGGTATGCGGGTACATACCTCTCCTTTATACCAGCG
CCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTTTTTATTACTGTTTAACCGTTCGGCCTGTCAAGCTTATGAACGG
TTATTTTTTATTGTTTTTCGTTGCTTCAAGGATACCGAAAATCAGTA

Structures

Antitoxin